FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2203994360> ?p ?o ?g. }

• W2203994360 endingPage "263" @default.
• W2203994360 startingPage "254" @default.
• W2203994360 abstract "Purinergic receptor activation via extracellular ATP is involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Nucleoside triphosphate diphosphohydrolase-1/CD39 hydrolyses extracellular ATP and modulates P2 receptor signalling.We aimed to investigate the expression and function of CD39 in the pathogenesis of cigarette smoke-induced lung inflammation in patients and preclinical mouse models. CD39 expression and soluble ATPase activity were quantified in sputum and bronchoalveolar lavage fluid (BALF) cells in nonsmokers, smokers and COPD patients or mice with cigarette smoke-induced lung inflammation. In mice, pulmonary ATP and cytokine concentrations, inflammation and emphysema were analysed in the presence or absence of CD39.Following acute cigarette smoke exposure CD39 was upregulated in BALF cells in smokers with further increases in COPD patients. Acute cigarette smoke exposure induced CD39 upregulation in murine lungs and BALF cells, and ATP degradation was accelerated in airway fluids. CD39 inhibition and deficiency led to augmented lung inflammation; treatment with ATPase during cigarette smoke exposure prevented emphysema.Pulmonary CD39 expression and activity are increased in COPD. CD39 deficiency leads to enhanced emphysema in mice, while external administration of a functional CD39 analogue partially rescues the phenotype. The compensatory upregulation of pulmonary CD39 might serve as a protective mechanism in cigarette smoke-induced lung damage." @default.
• W2203994360 created "2016-06-24" @default.
• W2203994360 creator A5012961044 @default.
• W2203994360 creator A5013031454 @default.
• W2203994360 creator A5013382939 @default.
• W2203994360 creator A5013868938 @default.
• W2203994360 creator A5022915762 @default.
• W2203994360 creator A5024495460 @default.
• W2203994360 creator A5025177458 @default.
• W2203994360 creator A5025395976 @default.
• W2203994360 creator A5031564190 @default.
• W2203994360 creator A5041621533 @default.
• W2203994360 creator A5044289288 @default.
• W2203994360 creator A5062879531 @default.
• W2203994360 creator A5066491154 @default.
• W2203994360 creator A5073697768 @default.
• W2203994360 creator A5081655212 @default.
• W2203994360 creator A5089408217 @default.
• W2203994360 date "2015-11-05" @default.
• W2203994360 modified "2023-10-13" @default.
• W2203994360 title "NTPDase1/CD39 and aberrant purinergic signalling in the pathogenesis of COPD" @default.
• W2203994360 cites W10146900 @default.
• W2203994360 cites W1526743741 @default.
• W2203994360 cites W1562182247 @default.
• W2203994360 cites W1922414080 @default.
• W2203994360 cites W1929822116 @default.
• W2203994360 cites W1972603857 @default.
• W2203994360 cites W1977040279 @default.
• W2203994360 cites W1979412100 @default.
• W2203994360 cites W1987062630 @default.
• W2203994360 cites W1988951550 @default.
• W2203994360 cites W1991608694 @default.
• W2203994360 cites W1994624849 @default.
• W2203994360 cites W2003262834 @default.
• W2203994360 cites W2025419815 @default.
• W2203994360 cites W2026143118 @default.
• W2203994360 cites W2026497490 @default.
• W2203994360 cites W2051529467 @default.
• W2203994360 cites W2056030227 @default.
• W2203994360 cites W2059177056 @default.
• W2203994360 cites W2060636124 @default.
• W2203994360 cites W2067223216 @default.
• W2203994360 cites W2068966082 @default.
• W2203994360 cites W2078544167 @default.
• W2203994360 cites W2085859589 @default.
• W2203994360 cites W2086556660 @default.
• W2203994360 cites W2094549432 @default.
• W2203994360 cites W2095988220 @default.
• W2203994360 cites W2096539359 @default.
• W2203994360 cites W2115349791 @default.
• W2203994360 cites W2129388928 @default.
• W2203994360 cites W2145067755 @default.
• W2203994360 cites W2146328930 @default.
• W2203994360 cites W2163178183 @default.
• W2203994360 cites W2277957658 @default.
• W2203994360 cites W2475686739 @default.
• W2203994360 cites W4211263216 @default.
• W2203994360 cites W4294183732 @default.
• W2203994360 cites W2074044485 @default.
• W2203994360 doi "https://doi.org/10.1183/13993003.02144-2014" @default.
• W2203994360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26541524" @default.
• W2203994360 hasPublicationYear "2015" @default.
• W2203994360 type Work @default.
• W2203994360 sameAs 2203994360 @default.
• W2203994360 citedByCount "24" @default.
• W2203994360 countsByYear W22039943602016 @default.
• W2203994360 countsByYear W22039943602017 @default.
• W2203994360 countsByYear W22039943602018 @default.
• W2203994360 countsByYear W22039943602019 @default.
• W2203994360 countsByYear W22039943602020 @default.
• W2203994360 countsByYear W22039943602021 @default.
• W2203994360 countsByYear W22039943602022 @default.
• W2203994360 countsByYear W22039943602023 @default.
• W2203994360 crossrefType "journal-article" @default.
• W2203994360 hasAuthorship W2203994360A5012961044 @default.
• W2203994360 hasAuthorship W2203994360A5013031454 @default.
• W2203994360 hasAuthorship W2203994360A5013382939 @default.
• W2203994360 hasAuthorship W2203994360A5013868938 @default.
• W2203994360 hasAuthorship W2203994360A5022915762 @default.
• W2203994360 hasAuthorship W2203994360A5024495460 @default.
• W2203994360 hasAuthorship W2203994360A5025177458 @default.
• W2203994360 hasAuthorship W2203994360A5025395976 @default.
• W2203994360 hasAuthorship W2203994360A5031564190 @default.
• W2203994360 hasAuthorship W2203994360A5041621533 @default.
• W2203994360 hasAuthorship W2203994360A5044289288 @default.
• W2203994360 hasAuthorship W2203994360A5062879531 @default.
• W2203994360 hasAuthorship W2203994360A5066491154 @default.
• W2203994360 hasAuthorship W2203994360A5073697768 @default.
• W2203994360 hasAuthorship W2203994360A5081655212 @default.
• W2203994360 hasAuthorship W2203994360A5089408217 @default.
• W2203994360 hasBestOaLocation W22039943601 @default.
• W2203994360 hasConcept C104317684 @default.
• W2203994360 hasConcept C126322002 @default.
• W2203994360 hasConcept C127561419 @default.
• W2203994360 hasConcept C170493617 @default.
• W2203994360 hasConcept C185592680 @default.
• W2203994360 hasConcept C203014093 @default.
• W2203994360 hasConcept C2776780178 @default.

• next