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- W2204007515 endingPage "311" @default.
- W2204007515 startingPage "269" @default.
- W2204007515 abstract "Most biopharmaceuticals, especially those of the first generation, are small proteins, which suffer from quick renal clearance and require frequent and/or high dosing to achieve clinical efficacy. A favorite strategy to create biobetters both from approved biologicals and based on new protein or peptide drug candidates is to prolong their time in circulation. This can be accomplished in two ways, either by conferring binding activity towards the neonatal Fc-receptor, to effect endosomal recycling, or by increasing the hydrodynamic molecular volume above the kidney pore size, thus retarding renal filtration. This chapter provides a comprehensive overview of currently available plasma half-life extension technologies including classical approaches like PEGylation, glycosylation, Fc or albumin fusion as well as novel strategies such as the use of biodegradable PEG mimetics based on carbohydrates (Sialysation, HEPtune) or hydrophilic amino acid polymers (XTEN or PASylation). Use of these technologies to engineer long-acting biobetters with higher efficacy and improved convenience for patients not only opens new treatment options but also offers profitable market opportunities." @default.
- W2204007515 created "2016-06-24" @default.
- W2204007515 creator A5025735412 @default.
- W2204007515 creator A5072379140 @default.
- W2204007515 date "2015-01-01" @default.
- W2204007515 modified "2023-09-27" @default.
- W2204007515 title "Current Strategies for Pharmacokinetic Optimization" @default.
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