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- W2204191294 abstract "Significance The human enzyme cytochrome P450 17A1 (CYP17A1) catalyzes the critical step in the biosynthesis of the male sex hormones, and, as such, it is a key target for the inhibition of testosterone production that is necessary for the progression of certain cancers. CYP17A1 catalyzes two distinct types of chemical transformations. The first is the hydroxylation of the steroid precursors pregnenolone and progesterone. The second is a different reaction involving carbon–carbon (C-C) bond cleavage, the mechanism of which has been actively debated in the literature. Using a combination of chemical and biophysical methods, we have been able to trap and characterize the active intermediate in this C-C lyase reaction, an important step in the potential design of mechanism-based inhibitors for the treatment of prostate cancers." @default.
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- W2204191294 date "2015-12-14" @default.
- W2204191294 modified "2023-10-16" @default.
- W2204191294 title "Unveiling the crucial intermediates in androgen production" @default.
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- W2204191294 doi "https://doi.org/10.1073/pnas.1519376113" @default.
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