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- W2204366321 abstract "Myxococcus xanthus development requires CsgA, a member of the short-chain alcohol dehydrogenase (SCAD) family of proteins. We show that CsgA and SocA, a protein that can replace CsgA function in vivo, oxidize the 2'-OH glycerol moiety on cardiolipin and phosphatidylglycerol to produce diacylglycerol (DAG), dihydroxyacetone, and orthophosphate. A lipid extract enriched in DAGs from wild-type cells initiates development and lipid body production in a csgA mutant to bypass the mutational block. This novel phospholipase C-like reaction is widespread. SCADs that prevent neurodegenerative disorders, such as Drosophila Sniffer and human HSD10, oxidize cardiolipin with similar kinetic parameters. HSD10 exhibits a strong preference for cardiolipin with oxidized fatty acids. This activity is inhibited in the presence of the amyloid β peptide. Three HSD10 variants associated with neurodegenerative disorders are inactive with cardiolipin. We suggest that HSD10 protects humans from reactive oxygen species by removing damaged cardiolipin before it induces apoptosis." @default.
- W2204366321 created "2016-06-24" @default.
- W2204366321 creator A5001914279 @default.
- W2204366321 creator A5084151152 @default.
- W2204366321 date "2015-09-03" @default.
- W2204366321 modified "2023-10-10" @default.
- W2204366321 title "<i>Myxococcus</i> CsgA, <i>Drosophila</i> Sniffer, and human HSD10 are cardiolipin phospholipases" @default.
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- W2204366321 cites W2013361289 @default.
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- W2204366321 doi "https://doi.org/10.1101/gad.268482.115" @default.
- W2204366321 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4579348" @default.
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