Matches in SemOpenAlex for { <https://semopenalex.org/work/W2204392835> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2204392835 endingPage "335" @default.
- W2204392835 startingPage "S" @default.
- W2204392835 abstract "istry (IHC). IECs were isolated and fractionated into cytosolic and nuclear fractions. p53 levels were assessed using WB and RT-PCR. Cleaved caspase-3 protein levels were assessed by WB. Target genes of p53 including survivin, p21, and Perp were measured using RTPCR. Results: WB of purified IECs 5 days after ICR revealed that nuclear p53 levels in the ICR mice were decreased compared to sham operated mice. Survivin, which is repressed by p53 transcription, was increased by RT-PCR (2-fold) and most dramatically by IHC with (3-5 fold) more survivin positive IEC staining through the lower to mid crypt regions in the ICR mice. We next examined other p53 target genes. Perp and p21 mRNA showed a 1.5 and 2 fold respective decreases in the RT-PCR of WT ICR as compared to sham surgery. Cleaved caspase-3 protein levels demonstrated a 2-fold decrease in the WT ICR as compared to sham surgery.Conclusions : The post-surgical epithelial responses after intestinal resection continue to be poorly understood. We demonstrated the importance of the down-regulation of p53 after ICR. As expected, survivin levels increased in the ICR mouse consistent with the notion that p53 repression and survivin induction contribute to the expanded surface area in ICR mice." @default.
- W2204392835 created "2016-06-24" @default.
- W2204392835 creator A5000540724 @default.
- W2204392835 creator A5010729232 @default.
- W2204392835 creator A5010842481 @default.
- W2204392835 creator A5023993084 @default.
- W2204392835 creator A5036209778 @default.
- W2204392835 creator A5037169243 @default.
- W2204392835 creator A5064117402 @default.
- W2204392835 creator A5066320242 @default.
- W2204392835 creator A5070369286 @default.
- W2204392835 creator A5081809589 @default.
- W2204392835 creator A5085902073 @default.
- W2204392835 creator A5086207567 @default.
- W2204392835 date "2012-05-01" @default.
- W2204392835 modified "2023-09-26" @default.
- W2204392835 title "Sa1829 Detection of Colonic Adenomas Using a Low-Cost, High Resolution Microendoscope: Assessment of Accuracy and Interobserver Variability" @default.
- W2204392835 doi "https://doi.org/10.1016/s0016-5085(12)61265-7" @default.
- W2204392835 hasPublicationYear "2012" @default.
- W2204392835 type Work @default.
- W2204392835 sameAs 2204392835 @default.
- W2204392835 citedByCount "0" @default.
- W2204392835 crossrefType "journal-article" @default.
- W2204392835 hasAuthorship W2204392835A5000540724 @default.
- W2204392835 hasAuthorship W2204392835A5010729232 @default.
- W2204392835 hasAuthorship W2204392835A5010842481 @default.
- W2204392835 hasAuthorship W2204392835A5023993084 @default.
- W2204392835 hasAuthorship W2204392835A5036209778 @default.
- W2204392835 hasAuthorship W2204392835A5037169243 @default.
- W2204392835 hasAuthorship W2204392835A5064117402 @default.
- W2204392835 hasAuthorship W2204392835A5066320242 @default.
- W2204392835 hasAuthorship W2204392835A5070369286 @default.
- W2204392835 hasAuthorship W2204392835A5081809589 @default.
- W2204392835 hasAuthorship W2204392835A5085902073 @default.
- W2204392835 hasAuthorship W2204392835A5086207567 @default.
- W2204392835 hasBestOaLocation W22043928351 @default.
- W2204392835 hasConcept C126838900 @default.
- W2204392835 hasConcept C138268822 @default.
- W2204392835 hasConcept C154945302 @default.
- W2204392835 hasConcept C41008148 @default.
- W2204392835 hasConcept C71924100 @default.
- W2204392835 hasConceptScore W2204392835C126838900 @default.
- W2204392835 hasConceptScore W2204392835C138268822 @default.
- W2204392835 hasConceptScore W2204392835C154945302 @default.
- W2204392835 hasConceptScore W2204392835C41008148 @default.
- W2204392835 hasConceptScore W2204392835C71924100 @default.
- W2204392835 hasIssue "5" @default.
- W2204392835 hasLocation W22043928351 @default.
- W2204392835 hasOpenAccess W2204392835 @default.
- W2204392835 hasPrimaryLocation W22043928351 @default.
- W2204392835 hasRelatedWork W141524600 @default.
- W2204392835 hasRelatedWork W1754602832 @default.
- W2204392835 hasRelatedWork W1841185769 @default.
- W2204392835 hasRelatedWork W1986465740 @default.
- W2204392835 hasRelatedWork W2049214470 @default.
- W2204392835 hasRelatedWork W2072926321 @default.
- W2204392835 hasRelatedWork W2137090458 @default.
- W2204392835 hasRelatedWork W2331072469 @default.
- W2204392835 hasRelatedWork W2748952813 @default.
- W2204392835 hasRelatedWork W2902148150 @default.
- W2204392835 hasVolume "142" @default.
- W2204392835 isParatext "false" @default.
- W2204392835 isRetracted "false" @default.
- W2204392835 magId "2204392835" @default.
- W2204392835 workType "article" @default.