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• W2204394468 abstract "Objective: To compare the clinical efficacy and systemic side effects of 2.5% and 10% phenylephrine for mydriasis in diabetic patient with darkly pigmented irides. Material and Method: A prospective randomized double-blind controlled trial was conducted. One hundred diabetic patients were randomly allocated into 2.5% and 10% phenylephrine groups by block randomization. Pupil diameter, blood pressure and heart rate were measured before and after eye drop instillations. Results: The mean pupil diameters after instillation in the right eye were 7.05 + 0.71 mm (2.5% phenylephrine group) and 7.40 + 0.72 mm (10% phenylephrine group, p = 0.02) and in the left eye were 7.05 + 0.72 mm (2.5% phenylephrine group) and 7.39 + 0.72 mm (10% phenylephrine group, p = 0.02). There was no clinically significant difference in mean heart rate, mean systolic and diastolic blood pressure. Conclusion : In diabetic patients with darkly pigmented irides, 10% phenylephrine is more effective than 2.5% phenylephrine with statistical significance. The authors recommend a single dose of 10% phenyleprine for mydriasis in these patients. However, the lower concentration is recommended for use in those who exhibit a higher prevalence of significant vascular disease and autonomic dysfunction and seem to be susceptible to severe adverse reaction of phenylephrine. Keywords: Phenylephrine, Mydriasis, Diabetes" @default.
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• W2204394468 date "2010-04-01" @default.
• W2204394468 modified "2023-09-26" @default.
• W2204394468 title "2.5% and 10% phenylephrine for mydriasis in diabetic patients with darkly pigmented irides." @default.
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