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- W2204478724 abstract "Previous investigations from our laboratory have shown that the benzene metabolite, hydroquinone (HQ), inhibits B cell production by preventing the maturation of pre-B cells. Data presented in this paper demonstrate that HQ interrupts B-lymphopoiesis indirectly by inhibiting the production of interleukin-4 (IL-4) by fibroblastic stromal cells. HQ exposure of fibroblastic stromal cells (SCL-173 and SCL-160) did not affect IL-4 production by these cell lines at any dose tested. Addition of untreated bone marrow-derived macrophages to HQ-treated bone marrow stromal cells (heterogeneous population of fibroblastic cells and macrophages) reversed inhibition of IL-4 production. However, addition of HQ-treated macrophages was without effect. Our studies suggest that HQ inhibits macrophage production of IL-1, a potent inducer of IL-4 production by bone marrow fibroblastic stromal cells. Interruption of IL-1 release from macrophages mediates the observed inhibition of B lineage cell maturation." @default.
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- W2204478724 date "1989-08-01" @default.
- W2204478724 modified "2023-09-27" @default.
- W2204478724 title "Bone marrow stromal cell regulation of B-lymphopoiesis. II. Mechanisms of hydroquinone inhibition of pre-B cell maturation." @default.
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