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- W2204611215 abstract "OBJECTIVE: Determine the effect of myasthenia on body composition.BACKGROUND: Little attention has been focused on long term consequences of chronic myasthenia gravis. Secondary biologic change in body composition, such as sarcopenia (loss of muscle bulk, strength, and function) and increased adiposity may have profound consequences on cardiopulmonary health and function.DESIGN/METHODS: 12 (5 female: 7 male) individuals with stable chronic myasthenia had body composition measures determined by anthropometrics, dual x-ray absorptiometry, and abdominal and thigh CT imaging and metabolic (cardiopulmonary peak and submaximal fitness determined by open circuit spirometry) and functional testing (timed walks, chair rises, and daily step activity).RESULTS: Subjects with myasthenia, aged 64 ± 8, had MG ADL Symptoms Scale 4 ± 3, Quantitative MG Score 5.5 ± 5.2, FVC 3.3 ± 0.6 L men, 1.6 ±0.6 L women), 30 meter gait speed 1.1 ± 0.2 m/s, timed get-up and go 9 ± 2 s, 5 chair rises 13.7 ±4.9 s, and daily steps 1,750 ± 650. Peak fitness level was 20.2 ± 5.5 ml/kg/min, this is 20[percnt] lower than age matched controls. Submaximal oxygen utilization was 13.3 ± 4.6 ml/kg/min with a resultant physiologic fitness reserve of 66 ± 11[percnt], which is more than twice that of age-matched controls.CONCLUSIONS: Subjects with myasthenia gravis have low muscle mass with correspondingly poor cardiovascular peak fitness level and diminished physiologic fitness reserve (requiring 66[percnt] of peak fitness is required to walk at a comfortable pace). Low daily step activity levels (1/3 age matched controls) may be one of the factors that leads to increase adiposity. This adiposity is under-estimated by standard formula for adiposity derived from body mass index (BMI) equations.Study Supported by: Myasthenia Gravis Foundation of America Disclosure: Dr. Hafer-Macko has nothing to disclose." @default.
- W2204611215 created "2016-06-24" @default.
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- W2204611215 date "2015-04-06" @default.
- W2204611215 modified "2023-09-24" @default.
- W2204611215 title "Sarcopenic Obesity in Myasthenia Gravis (P5.063)" @default.
- W2204611215 hasPublicationYear "2015" @default.
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