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- W2204920372 endingPage "e0145228" @default.
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- W2204920372 abstract "Herpes simplex virus 2 (HSV-2) 0ΔNLS is a live HSV-2 ICP0- mutant vaccine strain that is profoundly attenuated in vivo due to its interferon-hypersensitivity. Recipients of the HSV-2 0ΔNLS vaccine are resistant to high-dose HSV-2 challenge as evidenced by profound reductions in challenge virus spread, shedding, disease and mortality. In the current study, we investigated the requirements for HSV-2 0ΔNLS vaccine-induced protection. Studies using (UV)-inactivated HSV-2 0ΔNLS revealed that self-limited replication of the attenuated virus was required for effective protection from vaginal or ocular HSV-2 challenge. Diminished antibody responses in recipients of the UV-killed HSV-2 vaccine suggested that antibodies might be playing a critical role in early protection. This hypothesis was investigated in B-cell-deficient μMT mice. Vaccination with live HSV-2 0ΔNLS induced equivalent CD8+ T cell responses in wild-type and μMT mice. Vaccinated μMT mice shed ~40-fold more infectious HSV-2 at 24 hours post-challenge relative to vaccinated wild-type (B-cell+) mice, and most vaccinated μMT mice eventually succumbed to a slowly progressing HSV-2 challenge. Importantly, passive transfer of HSV-2 antiserum restored full protection to HSV-2 0ΔNLS-vaccinated μMT mice. The results demonstrate that B cells are required for complete vaccine-induced protection against HSV-2, and indicate that virus-specific antibodies are the dominant mediators of early vaccine-induced protection against HSV-2." @default.
- W2204920372 created "2016-06-24" @default.
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- W2204920372 creator A5067676121 @default.
- W2204920372 creator A5068146764 @default.
- W2204920372 date "2015-12-15" @default.
- W2204920372 modified "2023-10-14" @default.
- W2204920372 title "Antibodies Are Required for Complete Vaccine-Induced Protection against Herpes Simplex Virus 2" @default.
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- W2204920372 doi "https://doi.org/10.1371/journal.pone.0145228" @default.
- W2204920372 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4682860" @default.
- W2204920372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26670699" @default.
- W2204920372 hasPublicationYear "2015" @default.
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