Matches in SemOpenAlex for { <https://semopenalex.org/work/W2204988760> ?p ?o ?g. }
- W2204988760 endingPage "443" @default.
- W2204988760 startingPage "433" @default.
- W2204988760 abstract "Chikungunya virus (CHIKV) is an alphavirus responsible for causing epidemic outbreaks of polyarthralgia in humans. Because CHIKV is initially introduced via the skin, where γδ T cells are prevalent, we evaluated the response of these cells to CHIKV infection. CHIKV infection led to a significant increase in γδ T cells in the infected foot and draining lymph node that was associated with the production of proinflammatory cytokines and chemokines in C57BL/6J mice. γδ T cell(-/-) mice demonstrated exacerbated CHIKV disease characterized by less weight gain and greater foot swelling than occurred in wild-type mice, as well as a transient increase in monocytes and altered cytokine/chemokine expression in the foot. Histologically, γδ T cell(-/-) mice had increased inflammation-mediated oxidative damage in the ipsilateral foot and ankle joint compared to wild-type mice which was independent of differences in CHIKV replication. These results suggest that γδ T cells play a protective role in limiting the CHIKV-induced inflammatory response and subsequent tissue and joint damage.Recent epidemics, including the 2004 to 2007 outbreak and the spread of CHIKV to naive populations in the Caribbean and Central and South America with resultant cases imported into the United States, have highlighted the capacity of CHIKV to cause explosive epidemics where the virus can spread to millions of people and rapidly move into new areas. These studies identified γδ T cells as important to both recruitment of key inflammatory cell populations and dampening the tissue injury due to oxidative stress. Given the importance of these cells in the early response to CHIKV, this information may inform the development of CHIKV vaccines and therapeutics." @default.
- W2204988760 created "2016-06-24" @default.
- W2204988760 creator A5009633786 @default.
- W2204988760 creator A5018924367 @default.
- W2204988760 creator A5024135370 @default.
- W2204988760 creator A5036568474 @default.
- W2204988760 creator A5044640981 @default.
- W2204988760 creator A5051075405 @default.
- W2204988760 creator A5055923179 @default.
- W2204988760 creator A5062608685 @default.
- W2204988760 creator A5071206425 @default.
- W2204988760 date "2016-01-01" @default.
- W2204988760 modified "2023-10-15" @default.
- W2204988760 title "γδ T Cells Play a Protective Role in Chikungunya Virus-Induced Disease" @default.
- W2204988760 cites W1481699282 @default.
- W2204988760 cites W1493210615 @default.
- W2204988760 cites W1499138178 @default.
- W2204988760 cites W1517210971 @default.
- W2204988760 cites W1529543999 @default.
- W2204988760 cites W1583907297 @default.
- W2204988760 cites W1585900585 @default.
- W2204988760 cites W1607273785 @default.
- W2204988760 cites W180529491 @default.
- W2204988760 cites W1817849618 @default.
- W2204988760 cites W1928730528 @default.
- W2204988760 cites W1967239842 @default.
- W2204988760 cites W1968697332 @default.
- W2204988760 cites W1971143002 @default.
- W2204988760 cites W1972125983 @default.
- W2204988760 cites W1974514807 @default.
- W2204988760 cites W1975358757 @default.
- W2204988760 cites W1977296748 @default.
- W2204988760 cites W1977952791 @default.
- W2204988760 cites W1978038466 @default.
- W2204988760 cites W1981582579 @default.
- W2204988760 cites W1983091225 @default.
- W2204988760 cites W1984332517 @default.
- W2204988760 cites W1984727964 @default.
- W2204988760 cites W1985949976 @default.
- W2204988760 cites W1987105959 @default.
- W2204988760 cites W1989741953 @default.
- W2204988760 cites W1993712001 @default.
- W2204988760 cites W1995061768 @default.
- W2204988760 cites W2000190669 @default.
- W2204988760 cites W2001847828 @default.
- W2204988760 cites W2003114060 @default.
- W2204988760 cites W2004476696 @default.
- W2204988760 cites W2006232166 @default.
- W2204988760 cites W2015798128 @default.
- W2204988760 cites W2016270731 @default.
- W2204988760 cites W2017410453 @default.
- W2204988760 cites W2018084083 @default.
- W2204988760 cites W2021307858 @default.
- W2204988760 cites W2022930484 @default.
- W2204988760 cites W2024073376 @default.
- W2204988760 cites W2029111145 @default.
- W2204988760 cites W2030615310 @default.
- W2204988760 cites W2033325543 @default.
- W2204988760 cites W2033873890 @default.
- W2204988760 cites W2034377840 @default.
- W2204988760 cites W2035587893 @default.
- W2204988760 cites W2039313694 @default.
- W2204988760 cites W2053508100 @default.
- W2204988760 cites W2056953883 @default.
- W2204988760 cites W2058394330 @default.
- W2204988760 cites W2062504884 @default.
- W2204988760 cites W2064602529 @default.
- W2204988760 cites W2071048196 @default.
- W2204988760 cites W2076193648 @default.
- W2204988760 cites W20776671 @default.
- W2204988760 cites W2083116595 @default.
- W2204988760 cites W2086490184 @default.
- W2204988760 cites W2089479234 @default.
- W2204988760 cites W2093312902 @default.
- W2204988760 cites W20969374 @default.
- W2204988760 cites W2097446992 @default.
- W2204988760 cites W2098130096 @default.
- W2204988760 cites W2098311489 @default.
- W2204988760 cites W2110464701 @default.
- W2204988760 cites W2111608019 @default.
- W2204988760 cites W2114951959 @default.
- W2204988760 cites W2115381762 @default.
- W2204988760 cites W2119791199 @default.
- W2204988760 cites W2121005745 @default.
- W2204988760 cites W2121179501 @default.
- W2204988760 cites W2122206247 @default.
- W2204988760 cites W2123143464 @default.
- W2204988760 cites W2123263336 @default.
- W2204988760 cites W2124770252 @default.
- W2204988760 cites W2129436687 @default.
- W2204988760 cites W2131485514 @default.
- W2204988760 cites W2131612555 @default.
- W2204988760 cites W2133227616 @default.
- W2204988760 cites W2136689559 @default.
- W2204988760 cites W2141987735 @default.
- W2204988760 cites W2142039618 @default.
- W2204988760 cites W2145610587 @default.
- W2204988760 cites W2148093617 @default.