Matches in SemOpenAlex for { <https://semopenalex.org/work/W2205038181> ?p ?o ?g. }
- W2205038181 endingPage "92" @default.
- W2205038181 startingPage "77" @default.
- W2205038181 abstract "Learning Disabilities (LD) affect approximately 15% of the US population, but currently there are no generally effective therapies for this class of cognitive disorders. To address this problem, it has been initially focused on Neurofibromatosis type I (NF1), a single gene disorder associated with learning disabilities. Previous studies showed that mice with a heterozygous null mutation of the NF1 gene have behavioral deficits related to the cognitive phenotype of NF1 patients. Studies of these mice showed increased Ras/MAPK signaling in the hippocampus and prefrontal cortex, which results in the upregulation of GABA release underlying the spatial, attention and working memory deficits of the mutants. Statins can be used to decrease the isoprenylation; therefore, the activity of Ras. Recent results demonstrate that a short treatment with statins, which is ineffective in controls, can reverse the increases in Ras-MAPK signaling, the synaptic plasticity, attention, and spatial learning deficits of the NF1 mutant mice. To test whether statins can also reverse the neurological and cognitive deficits associated with NF1 in patients, a series of collaborative pilot clinical studies in children and adults with NF1 has been initiated. These studies will not only have an impact on the understanding of cognitive deficits associated with NF1, it will also serve as a case study for how to investigate and treat learning disabilities." @default.
- W2205038181 created "2016-06-24" @default.
- W2205038181 creator A5001957878 @default.
- W2205038181 creator A5002587685 @default.
- W2205038181 creator A5014858033 @default.
- W2205038181 creator A5016283139 @default.
- W2205038181 creator A5018416759 @default.
- W2205038181 creator A5032062559 @default.
- W2205038181 creator A5035396358 @default.
- W2205038181 creator A5041003871 @default.
- W2205038181 creator A5057123236 @default.
- W2205038181 creator A5060553079 @default.
- W2205038181 creator A5074595624 @default.
- W2205038181 date "2008-01-01" @default.
- W2205038181 modified "2023-10-16" @default.
- W2205038181 title "Molecular and Cellular Mechanisms of Learning Disabilities: A Focus on Neurofibromatosis Type I" @default.
- W2205038181 cites W1504111015 @default.
- W2205038181 cites W1531938074 @default.
- W2205038181 cites W1567873511 @default.
- W2205038181 cites W1606326824 @default.
- W2205038181 cites W1622746725 @default.
- W2205038181 cites W1673160816 @default.
- W2205038181 cites W1871911763 @default.
- W2205038181 cites W1876061808 @default.
- W2205038181 cites W1968834749 @default.
- W2205038181 cites W1970006557 @default.
- W2205038181 cites W1971602793 @default.
- W2205038181 cites W1975776306 @default.
- W2205038181 cites W1988048905 @default.
- W2205038181 cites W1992543740 @default.
- W2205038181 cites W1993281814 @default.
- W2205038181 cites W1994115179 @default.
- W2205038181 cites W1995920979 @default.
- W2205038181 cites W1997613260 @default.
- W2205038181 cites W1998431650 @default.
- W2205038181 cites W1998725350 @default.
- W2205038181 cites W2003825411 @default.
- W2205038181 cites W2009779410 @default.
- W2205038181 cites W2011270087 @default.
- W2205038181 cites W2013355993 @default.
- W2205038181 cites W2017444651 @default.
- W2205038181 cites W2020231002 @default.
- W2205038181 cites W2022096471 @default.
- W2205038181 cites W2022323532 @default.
- W2205038181 cites W2023395361 @default.
- W2205038181 cites W2023796149 @default.
- W2205038181 cites W2030645204 @default.
- W2205038181 cites W2036567739 @default.
- W2205038181 cites W2041609008 @default.
- W2205038181 cites W2043682910 @default.
- W2205038181 cites W2044356784 @default.
- W2205038181 cites W2046990491 @default.
- W2205038181 cites W2047977471 @default.
- W2205038181 cites W2049776725 @default.
- W2205038181 cites W2050831289 @default.
- W2205038181 cites W2054379134 @default.
- W2205038181 cites W2054672127 @default.
- W2205038181 cites W2055911520 @default.
- W2205038181 cites W2069935187 @default.
- W2205038181 cites W2071090720 @default.
- W2205038181 cites W2072478579 @default.
- W2205038181 cites W2076935577 @default.
- W2205038181 cites W2079330190 @default.
- W2205038181 cites W2079517986 @default.
- W2205038181 cites W2081688596 @default.
- W2205038181 cites W2093423802 @default.
- W2205038181 cites W2096229412 @default.
- W2205038181 cites W2100183692 @default.
- W2205038181 cites W2104568873 @default.
- W2205038181 cites W2105248638 @default.
- W2205038181 cites W2110176970 @default.
- W2205038181 cites W2117823415 @default.
- W2205038181 cites W2118469169 @default.
- W2205038181 cites W2129789527 @default.
- W2205038181 cites W2130690907 @default.
- W2205038181 cites W2136881248 @default.
- W2205038181 cites W2144373719 @default.
- W2205038181 cites W2144985470 @default.
- W2205038181 cites W2149675711 @default.
- W2205038181 cites W2150281941 @default.
- W2205038181 cites W2156236227 @default.
- W2205038181 cites W2156962646 @default.
- W2205038181 cites W2159562139 @default.
- W2205038181 cites W2163253596 @default.
- W2205038181 cites W2164938664 @default.
- W2205038181 cites W2166376912 @default.
- W2205038181 cites W2168640086 @default.
- W2205038181 cites W2171691063 @default.
- W2205038181 cites W2418221041 @default.
- W2205038181 cites W2496618795 @default.
- W2205038181 cites W96875381 @default.
- W2205038181 cites W2117296940 @default.
- W2205038181 doi "https://doi.org/10.1016/b978-0-12-373861-5.00015-1" @default.
- W2205038181 hasPublicationYear "2008" @default.
- W2205038181 type Work @default.
- W2205038181 sameAs 2205038181 @default.
- W2205038181 citedByCount "0" @default.
- W2205038181 crossrefType "book-chapter" @default.