Matches in SemOpenAlex for { <https://semopenalex.org/work/W2205088382> ?p ?o ?g. }
- W2205088382 endingPage "42612" @default.
- W2205088382 startingPage "42603" @default.
- W2205088382 abstract "// Mara Brancaccio 1 , Stefania Rocca 1 , Laura Seclì 1 , Elena Busso 1 and Federica Fusella 1 1 Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy Correspondence to: Mara Brancaccio, email: // Keywords : Morgana, chord containing protein, ROCK, atypical chronic myeloid leukemia, chemoresistance Received : July 13, 2015 Accepted : September 24, 2015 Published : October 09, 2015 Abstract Morgana is a chaperone protein able to bind to ROCK I and II and to inhibit their kinase activity. Rho kinases are multifunctional proteins involved in different cellular processes, including cytoskeleton organization, centrosome duplication, cell survival and proliferation. In human cancer samples Morgana appears to be either downregulated or overexpressed, and experimental evidence indicate that Morgana behaves both as an oncosuppressor and as a proto-oncogene. Our most recent findings demonstrated that if on the one hand low Morgana expression levels, by inducing ROCK II hyperactivation, cause centrosome overduplication and genomic instability, on the other hand, Morgana overexpression induces tumor cell survival and chemoresistance through the ROCK I-PTEN-AKT axis. Therefore, Morgana belongs to a new class of proteins, displaying both oncogenic and oncosuppressor features, depending on the specific cellular context." @default.
- W2205088382 created "2016-06-24" @default.
- W2205088382 creator A5002700849 @default.
- W2205088382 creator A5046747249 @default.
- W2205088382 creator A5054519058 @default.
- W2205088382 creator A5057698241 @default.
- W2205088382 creator A5075548163 @default.
- W2205088382 date "2015-10-09" @default.
- W2205088382 modified "2023-09-27" @default.
- W2205088382 title "The double face of Morgana in tumorigenesis" @default.
- W2205088382 cites W1624229476 @default.
- W2205088382 cites W1811043827 @default.
- W2205088382 cites W1965196045 @default.
- W2205088382 cites W1966851583 @default.
- W2205088382 cites W1968592557 @default.
- W2205088382 cites W1976615153 @default.
- W2205088382 cites W1979778041 @default.
- W2205088382 cites W1980498609 @default.
- W2205088382 cites W1980918954 @default.
- W2205088382 cites W1982551629 @default.
- W2205088382 cites W1987807346 @default.
- W2205088382 cites W1988579829 @default.
- W2205088382 cites W2002280519 @default.
- W2205088382 cites W2002373478 @default.
- W2205088382 cites W2002595295 @default.
- W2205088382 cites W2003046264 @default.
- W2205088382 cites W2004280628 @default.
- W2205088382 cites W2006675810 @default.
- W2205088382 cites W2007580297 @default.
- W2205088382 cites W2014141207 @default.
- W2205088382 cites W2015408520 @default.
- W2205088382 cites W2016886749 @default.
- W2205088382 cites W2023568503 @default.
- W2205088382 cites W2023651395 @default.
- W2205088382 cites W2030402531 @default.
- W2205088382 cites W2034091134 @default.
- W2205088382 cites W2040359462 @default.
- W2205088382 cites W2045173243 @default.
- W2205088382 cites W2046178435 @default.
- W2205088382 cites W2047245215 @default.
- W2205088382 cites W2051736949 @default.
- W2205088382 cites W2060369462 @default.
- W2205088382 cites W2062470451 @default.
- W2205088382 cites W2065285374 @default.
- W2205088382 cites W2066482548 @default.
- W2205088382 cites W2068195625 @default.
- W2205088382 cites W2069202959 @default.
- W2205088382 cites W2069271377 @default.
- W2205088382 cites W2073261165 @default.
- W2205088382 cites W2074672025 @default.
- W2205088382 cites W2077718534 @default.
- W2205088382 cites W2077834462 @default.
- W2205088382 cites W2079336387 @default.
- W2205088382 cites W2080469841 @default.
- W2205088382 cites W2080631729 @default.
- W2205088382 cites W2081245863 @default.
- W2205088382 cites W2081290563 @default.
- W2205088382 cites W2082627145 @default.
- W2205088382 cites W2085826209 @default.
- W2205088382 cites W2093169681 @default.
- W2205088382 cites W2096027508 @default.
- W2205088382 cites W2097238709 @default.
- W2205088382 cites W2099170646 @default.
- W2205088382 cites W2103237568 @default.
- W2205088382 cites W2105666596 @default.
- W2205088382 cites W2105783133 @default.
- W2205088382 cites W2107928168 @default.
- W2205088382 cites W2114459416 @default.
- W2205088382 cites W2117957791 @default.
- W2205088382 cites W2123621576 @default.
- W2205088382 cites W2126008912 @default.
- W2205088382 cites W2130408098 @default.
- W2205088382 cites W2131147451 @default.
- W2205088382 cites W2133490913 @default.
- W2205088382 cites W2137752053 @default.
- W2205088382 cites W2138253156 @default.
- W2205088382 cites W2141266668 @default.
- W2205088382 cites W2142612272 @default.
- W2205088382 cites W2146146853 @default.
- W2205088382 cites W2147208780 @default.
- W2205088382 cites W2153870676 @default.
- W2205088382 cites W2154691400 @default.
- W2205088382 cites W2161447932 @default.
- W2205088382 cites W2167008303 @default.
- W2205088382 cites W2168075712 @default.
- W2205088382 cites W2169328538 @default.
- W2205088382 cites W2324450197 @default.
- W2205088382 cites W4233431843 @default.
- W2205088382 doi "https://doi.org/10.18632/oncotarget.6058" @default.
- W2205088382 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4767456" @default.
- W2205088382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26460959" @default.
- W2205088382 hasPublicationYear "2015" @default.
- W2205088382 type Work @default.
- W2205088382 sameAs 2205088382 @default.
- W2205088382 citedByCount "7" @default.
- W2205088382 countsByYear W22050883822016 @default.
- W2205088382 countsByYear W22050883822017 @default.
- W2205088382 countsByYear W22050883822018 @default.