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• W2205097744 abstract "Proton pump inhibitors (PPIs) are among the most commonly prescribed medicines and overuse is widespread in both primary and secondary care [ [1] Forgacs I. Loganayagam A. Overprescribing proton pump inhibitors. BMJ. 2008; 336: 2-3 Crossref PubMed Scopus (386) Google Scholar ]. Although generally well tolerated, PPIs can cause serious adverse reactions, such as community-acquired pneumonia, Clostridium difficile diarrhea [ [2] Johnson D.A. Oldfield E.C. Reported side effects and complications of long-term proton pump inhibitor use: dissecting the evidence. Clin Gastroenterol Hepatol. 2013; 11: 458-464 Abstract Full Text Full Text PDF PubMed Scopus (85) Google Scholar ] or hip fractures [ 3 Targownik L.E. Lix L.M. Metge C.J. Prior H.J. Leung S. Leslie W.D. Use of proton pump inhibitors and risk of osteoporosis related fractures. CMAJ. 2008; 179: 319-326 Crossref PubMed Scopus (348) Google Scholar , 4 Yang Y.X. Metz D.C. Safety of proton pump inhibitor exposure. Gastroenterology. 2010 Oct; 139: 1115-1127 Abstract Full Text Full Text PDF PubMed Scopus (177) Google Scholar ] and have been reported to increase all-cause mortality [ [5] Maggio M. Corsonello A. Ceda G.P. Cattabiani C. Lauretani F. Buttò V. et al. Proton pump inhibitors and risk of 1-year mortality and rehospitalization in older patients discharged from acute care hospitals. JAMA Intern Med. 2013; 173: 518-523 Crossref PubMed Scopus (87) Google Scholar ]. PPI-associated hypomagnesemia is a rare but potentially life-threatening side-effect that has recently emerged as a consequence of their massive use, but the prevalence has not been established [ 6 Furlanetto T.W. Faulhaber G.A. Hypomagnesemia and proton pump inhibitors: below the tip of the iceberg. Arch Intern Med. 2011 Aug 8; 171: 1391-1392 Crossref PubMed Scopus (52) Google Scholar , 7 Cundy T. Mackay J. Proton pump inhibitors and severe hypomagnesaemia. Curr Opin Gastroenterol. 2011; 27: 180-185 Crossref PubMed Scopus (97) Google Scholar , 8 Zipursky J. Macdonald E.M. Hollands S. Gomes T. Mamdani M.M. Paterson J.M. et al. Proton pump inhibitors and hospitalization with hypomagnesemia: a population-based case–control study. PLoS Med. 2014; 11 Crossref PubMed Scopus (52) Google Scholar ]. Long duration of PPI use has been suggested as a probable risk factor, but causality has not been established. No single indication for PPI use or dosage has been associated with hypomagnesemia and the risk of concomitant consumption of diuretics, which could contribute to the development of hypomagnesemia [ 7 Cundy T. Mackay J. Proton pump inhibitors and severe hypomagnesaemia. Curr Opin Gastroenterol. 2011; 27: 180-185 Crossref PubMed Scopus (97) Google Scholar , 8 Zipursky J. Macdonald E.M. Hollands S. Gomes T. Mamdani M.M. Paterson J.M. et al. Proton pump inhibitors and hospitalization with hypomagnesemia: a population-based case–control study. PLoS Med. 2014; 11 Crossref PubMed Scopus (52) Google Scholar ], is also not clear." @default.
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• W2205097744 title "Proton pump inhibitors and risk of hypomagnesemia" @default.
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