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- W2205177304 abstract "Vasculogenic mimicry (VM) describes the process by which aggressive cancer cells form extracellular matrix-rich, vessel-like mesh works, which supply nutrients and oxygen. Furthermore, it offers a new route for tumor cell invasion and metastasis and thus a correspondingly poor prognosis and survival rate for affected patients. Effector caspases are well known for their apoptotic function, whereas a non-apoptotic function in tumor progression is highly disputed. Caspase-3, -6 and -7 are expressed in aggressive tumor cells in a non-mutated form, indicating an active function independent of apoptosis. This review summarizes the possible functions of the above-mentioned caspases in VM. We also discuss the possible involvement of caspases in potential mechanisms towards the formation of vessel-like structures. Furthermore, this review illustrates the importance of new studies in the ongoing investigation into the role of effector caspases in VM, invasion, and migration of aggressive tumor cells." @default.
- W2205177304 created "2016-06-24" @default.
- W2205177304 creator A5007653727 @default.
- W2205177304 creator A5076554970 @default.
- W2205177304 date "2016-03-01" @default.
- W2205177304 modified "2023-10-06" @default.
- W2205177304 title "Vasculogenic mimicry: Possible role of effector caspase-3, caspase-6 and caspase-7" @default.
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- W2205177304 doi "https://doi.org/10.1016/j.aanat.2015.11.007" @default.
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