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- W2205545580 abstract "We introduce and describe a novel non-invasive in-vivo method for mapping local rod rhodopsin distribution in the human retina over a 30-degree field. Our approach is based on analyzing the brightening of detected lipofuscin autofluorescence within small pixel clusters in registered imaging sequences taken with a commercial 488nm confocal scanning laser ophthalmoscope (cSLO) over a 1 minute period. We modeled the kinetics of rhodopsin bleaching by applying variational optimization techniques from applied mathematics. The physical model and the numerical analysis with its implementation are outlined in detail. This new technique enables the creation of spatial maps of the retinal rhodopsin and retinal pigment epithelium (RPE) bisretinoid distribution with an ≈ 50μm resolution." @default.
- W2205545580 created "2016-06-24" @default.
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- W2205545580 date "2015-07-21" @default.
- W2205545580 modified "2023-09-25" @default.
- W2205545580 title "Modeling Photo-Bleaching Kinetics to Create High Resolution Maps of Rod Rhodopsin in the Human Retina" @default.
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- W2205545580 doi "https://doi.org/10.1371/journal.pone.0131881" @default.
- W2205545580 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4510609" @default.
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