Matches in SemOpenAlex for { <https://semopenalex.org/work/W2205591306> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2205591306 endingPage "7" @default.
- W2205591306 startingPage "244" @default.
- W2205591306 abstract "To develop a high performance liquid chromatography system for the determination of a new 1,4-dihydropyridine, mebudipine, in rabbit plasma.To 1 ml of rabbit plasma was added internal standard (dibudipine) and 0.5 ml of 1 M NaOH. Mebudipine and internal standard were extracted to 5 ml ethyl acetate, evaporated under slow stream of nitrogen. The residue was reconstituted in 200 microl mobile phase and 20 microl of aliquots were injected into a HPLC system equipped with 4.6 x 250 mm i.d. C18 analytical column. Mobile phase consisted of methanol (70%), water (25%) and acetonitril (5%) and its flow rate was 1 ml/min.There were no interfering peaks from endogenous components in blank plasma chromatograms. Standard curves were linear (r(2)>0.99) over 10 to 500 ng/ml. The extraction efficiency was >90% and the minimum quantifiable concentration was 10 ng/ml (CV<10%).A suitable, convenient and simple HPLC assay for pharmacokinetic study of mebudipine in rabbits was developed." @default.
- W2205591306 created "2016-06-24" @default.
- W2205591306 creator A5048308649 @default.
- W2205591306 creator A5058000432 @default.
- W2205591306 creator A5072445079 @default.
- W2205591306 date "2001-12-12" @default.
- W2205591306 modified "2023-09-23" @default.
- W2205591306 title "High performance liquid chromatography of mebudipine: application to pharmacokinetic study." @default.
- W2205591306 cites W2035220494 @default.
- W2205591306 cites W2074444547 @default.
- W2205591306 cites W2307858567 @default.
- W2205591306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11737990" @default.
- W2205591306 hasPublicationYear "2001" @default.
- W2205591306 type Work @default.
- W2205591306 sameAs 2205591306 @default.
- W2205591306 citedByCount "4" @default.
- W2205591306 countsByYear W22055913062015 @default.
- W2205591306 crossrefType "journal-article" @default.
- W2205591306 hasAuthorship W2205591306A5048308649 @default.
- W2205591306 hasAuthorship W2205591306A5058000432 @default.
- W2205591306 hasAuthorship W2205591306A5072445079 @default.
- W2205591306 hasConcept C112705442 @default.
- W2205591306 hasConcept C126322002 @default.
- W2205591306 hasConcept C179998833 @default.
- W2205591306 hasConcept C185592680 @default.
- W2205591306 hasConcept C2779858419 @default.
- W2205591306 hasConcept C2781338088 @default.
- W2205591306 hasConcept C43617362 @default.
- W2205591306 hasConcept C4725764 @default.
- W2205591306 hasConcept C55493867 @default.
- W2205591306 hasConcept C70784841 @default.
- W2205591306 hasConcept C71924100 @default.
- W2205591306 hasConceptScore W2205591306C112705442 @default.
- W2205591306 hasConceptScore W2205591306C126322002 @default.
- W2205591306 hasConceptScore W2205591306C179998833 @default.
- W2205591306 hasConceptScore W2205591306C185592680 @default.
- W2205591306 hasConceptScore W2205591306C2779858419 @default.
- W2205591306 hasConceptScore W2205591306C2781338088 @default.
- W2205591306 hasConceptScore W2205591306C43617362 @default.
- W2205591306 hasConceptScore W2205591306C4725764 @default.
- W2205591306 hasConceptScore W2205591306C55493867 @default.
- W2205591306 hasConceptScore W2205591306C70784841 @default.
- W2205591306 hasConceptScore W2205591306C71924100 @default.
- W2205591306 hasIssue "3" @default.
- W2205591306 hasLocation W22055913061 @default.
- W2205591306 hasOpenAccess W2205591306 @default.
- W2205591306 hasPrimaryLocation W22055913061 @default.
- W2205591306 hasRelatedWork W1588095382 @default.
- W2205591306 hasRelatedWork W1998021298 @default.
- W2205591306 hasRelatedWork W2034449809 @default.
- W2205591306 hasRelatedWork W2091605586 @default.
- W2205591306 hasRelatedWork W2205591306 @default.
- W2205591306 hasRelatedWork W2360413115 @default.
- W2205591306 hasRelatedWork W2360682622 @default.
- W2205591306 hasRelatedWork W2412066373 @default.
- W2205591306 hasRelatedWork W2603470637 @default.
- W2205591306 hasRelatedWork W1968397378 @default.
- W2205591306 hasVolume "4" @default.
- W2205591306 isParatext "false" @default.
- W2205591306 isRetracted "false" @default.
- W2205591306 magId "2205591306" @default.
- W2205591306 workType "article" @default.