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• W2205597788 endingPage "331" @default.
• W2205597788 startingPage "261" @default.
• W2205597788 abstract "This chapter discusses the structure–activity relationships that are summarized by emphasizing the common structural features of nearly all active anticonvulsants. It seems probable that most of the possible variations on this single theme have been very extensively explored, and it is unlikely that a major advance in therapy results from a further study of the same chemical class. The chapter further reviews the studies of the mode of action of anaesthetic, sedative, and anticonvulsant drugs. The number of methods of testing anticonvulsants much exceeds the number of successful anticonvulsants. The most used methods cause seizures in animals either electrically or by administering a chemical convulsant, particularly leptazol. The chapter also reviews that Audiogenic seizures have been used to study actions of anticonvulsant and other drugs. The two main components are a running seizure, succeeded by a clonic-tonic-clonic seizure. Anticonvulsants seem much more effective against the tonic extensor component of the maximal audiogenic seizure than against the running component. The method offers no obvious advantage over electrical tests. The same is probably true of seizures caused by high oxygen pressures. A major advance is more likely to result from further variation of the familiar structures, or from blind screening of thousands of compounds. The second requirement is for more precise and delicate methods of detecting promising anticonvulsants." @default.
• W2205597788 created "2016-06-24" @default.
• W2205597788 creator A5033513376 @default.
• W2205597788 creator A5055430539 @default.
• W2205597788 date "1963-01-01" @default.
• W2205597788 modified "2023-09-25" @default.
• W2205597788 title "6 Anticonvulsant Drugs" @default.
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