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• W2205661330 abstract "Background Discontinuation of E. coli l ‐asparaginase in patients with acute lymphoblastic leukemia (ALL) is unavoidable upon severe allergic reaction. We sought to examine outcomes following E. coli l ‐asparaginase discontinuation due to severe allergic reactions. Procedure We evaluated the outcome of children enrolled in Taiwan Pediatric Oncology Group‐2002‐ALL protocol between 2002 and 2012, who had E. coli l ‐asparaginase discontinued due to severe allergic reactions, and compared the outcomes of those who continued with Erwinia l ‐asparaginase (Erwinase) with those who did not. Results Among 700 patients enrolled in this study, 33 patients had E. coli l ‐asparaginase treatment discontinued due to severe allergic reactions. Five‐year overall survival did not differ significantly among the 648 patients without discontinuation (81 ± 1.6%, mean ± SE), compared to 17 patients with allergic reactions and treated with Erwinase (88 ± 7.8%) and 16 patients with allergic reactions but not treated with Erwinase (87 ± 8.6%). Among 16 patients who did not receive Erwinase, all 10 who received ≥50% of the scheduled doses of E. coli l ‐asparaginase before discontinuation survived without events. Conclusions Erwinase treatment may not be needed for some ALL patients with severe allergy to E. coli l ‐asparaginase if ≥50% of prescribed doses were received and/or therapy is augmented with other agents." @default.
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• W2205661330 date "2015-12-24" @default.
• W2205661330 modified "2023-10-12" @default.
• W2205661330 title "Outcomes Following Discontinuation of<i>E. coli</i><scp>l</scp>-Asparaginase Upon Severe Allergic Reactions in Children With Acute Lymphoblastic Leukemia" @default.
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• W2205661330 doi "https://doi.org/10.1002/pbc.25869" @default.
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