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- W2205750076 abstract "Background: The Cockcroft-Gault (C-G) formula has been widely used to substitute for 24-hour creatinine clearance (24-hour Ccr) in estimating the glomerular filtration rate, but in our previous study, it underestimated the 24-hour Ccr markedly in advanced-stage non-small lung cancer (NSCLC) patients. It has been reported that there is a very high correlation between urinary creatinine excretion (Ucr) and lean body mass (LBM). The purpose of this study was to evaluate the feasibility of using LBM measured by bioelectrical impedance analysis (BIA) to estimate the 24-hour Ccr in advanced-stage NSCLC patients. Methods: Eighty-four patients with advanced NSCLC, who were admitted for the first cycle of chemotherapy, participated in this study. Twenty-four-hour urine was collected and LBM was obtained by BIA before chemotherapy. We evaluated whether or not there was a significant correlation between 24-hour Ucr and LBM. If there was, LBM was used to estimate 24-hour Ucr, thus 24-hour Ccr. The creatinine clearance predicted from LBM measured by the BIA method (LBM Ccr) and C-G formula (C-G Ccr) was compared to the 24-hour Ccr. Results: There was a significant correlation between LBM and 24-hour Ucr (r=0.798). The Ccr obtained by the C-G formula underestimated the 24-hour Ccr by a mean of 12.3 ml/min. The LBM Ccr was highly correlated with 24-hour Ccr (r=0.848), with a mean difference of 0.1 ml/min. The agreement of predicted Ccr, using LBM measured by the BIA method and the C-G formula with 24-hour Ccr, was similar. Conclusion: The C-G formula underestimated the 24-hour Ccr significantly in patients with advanced-stage NSCLC. LBM measured by the BIA method was significantly correlated with 24-hour Ucr. It is feasible to predict 24-hour Ccr using LBM measured by the BIA method in these patients." @default.
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- W2205750076 date "2007-02-01" @default.
- W2205750076 modified "2023-09-28" @default.
- W2205750076 title "Accurate Estimation of Creatinine Clearance Based on Lean Body Mass Measured by Bioelectrical Impedance Analysis in Non-Small Cell Lung Cancer" @default.
- W2205750076 doi "https://doi.org/10.29806/tm.200702.0002" @default.
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