Matches in SemOpenAlex for { <https://semopenalex.org/work/W2205934982> ?p ?o ?g. }
- W2205934982 endingPage "3061" @default.
- W2205934982 startingPage "3049" @default.
- W2205934982 abstract "Inositol polyphosphate 4-phosphatase type II (INPP4B) negatively regulates phosphatidylinositol 3-kinase signaling and is a tumor suppressor in some types of cancers. However, we have found that it is frequently upregulated in human colon cancer cells. Here we show that silencing of INPP4B blocks activation of Akt and serum- and glucocorticoid-regulated kinase 3 (SGK3), inhibits colon cancer cell proliferation and retards colon cancer xenograft growth. Conversely, overexpression of INPP4B increases proliferation and triggers anchorage-independent growth of normal colon epithelial cells. Moreover, we demonstrate that the effect of INPP4B on Akt and SGK3 is associated with inactivation of phosphate and tensin homolog through its protein phosphatase activity and that the increase in INPP4B is due to Ets-1-mediated transcriptional upregulation in colon cancer cells. Collectively, these results suggest that INPP4B may function as an oncogenic driver in colon cancer, with potential implications for targeting INPP4B as a novel approach to treat this disease." @default.
- W2205934982 created "2016-06-24" @default.
- W2205934982 creator A5002450468 @default.
- W2205934982 creator A5003787100 @default.
- W2205934982 creator A5006168466 @default.
- W2205934982 creator A5007435283 @default.
- W2205934982 creator A5007604152 @default.
- W2205934982 creator A5015872707 @default.
- W2205934982 creator A5016817677 @default.
- W2205934982 creator A5019145198 @default.
- W2205934982 creator A5019722118 @default.
- W2205934982 creator A5034532201 @default.
- W2205934982 creator A5034549592 @default.
- W2205934982 creator A5038117448 @default.
- W2205934982 creator A5041063715 @default.
- W2205934982 creator A5044092723 @default.
- W2205934982 creator A5045130561 @default.
- W2205934982 creator A5046335734 @default.
- W2205934982 creator A5048324114 @default.
- W2205934982 creator A5048927086 @default.
- W2205934982 creator A5057520512 @default.
- W2205934982 creator A5057886721 @default.
- W2205934982 creator A5058536744 @default.
- W2205934982 creator A5064183268 @default.
- W2205934982 creator A5072813429 @default.
- W2205934982 creator A5075932088 @default.
- W2205934982 date "2015-09-28" @default.
- W2205934982 modified "2023-10-18" @default.
- W2205934982 title "INPP4B is an oncogenic regulator in human colon cancer" @default.
- W2205934982 cites W1484784716 @default.
- W2205934982 cites W1970741481 @default.
- W2205934982 cites W1972178925 @default.
- W2205934982 cites W1979284427 @default.
- W2205934982 cites W1989408768 @default.
- W2205934982 cites W2006771504 @default.
- W2205934982 cites W2009516619 @default.
- W2205934982 cites W2012116166 @default.
- W2205934982 cites W2012161562 @default.
- W2205934982 cites W2021287122 @default.
- W2205934982 cites W2023543654 @default.
- W2205934982 cites W2025605504 @default.
- W2205934982 cites W2026145775 @default.
- W2205934982 cites W2028626714 @default.
- W2205934982 cites W2029729683 @default.
- W2205934982 cites W2033324594 @default.
- W2205934982 cites W2035258932 @default.
- W2205934982 cites W2041061216 @default.
- W2205934982 cites W2055979093 @default.
- W2205934982 cites W2059259875 @default.
- W2205934982 cites W2062144817 @default.
- W2205934982 cites W2073910094 @default.
- W2205934982 cites W2084136291 @default.
- W2205934982 cites W2088467967 @default.
- W2205934982 cites W2092676832 @default.
- W2205934982 cites W2094068658 @default.
- W2205934982 cites W2106278322 @default.
- W2205934982 cites W2109559424 @default.
- W2205934982 cites W2109847775 @default.
- W2205934982 cites W2111223585 @default.
- W2205934982 cites W2119581553 @default.
- W2205934982 cites W2121945278 @default.
- W2205934982 cites W2145169016 @default.
- W2205934982 cites W2154853638 @default.
- W2205934982 cites W2156266404 @default.
- W2205934982 cites W2159801541 @default.
- W2205934982 cites W2165575558 @default.
- W2205934982 cites W68672284 @default.
- W2205934982 doi "https://doi.org/10.1038/onc.2015.361" @default.
- W2205934982 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4908438" @default.
- W2205934982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26411369" @default.
- W2205934982 hasPublicationYear "2015" @default.
- W2205934982 type Work @default.
- W2205934982 sameAs 2205934982 @default.
- W2205934982 citedByCount "51" @default.
- W2205934982 countsByYear W22059349822016 @default.
- W2205934982 countsByYear W22059349822017 @default.
- W2205934982 countsByYear W22059349822018 @default.
- W2205934982 countsByYear W22059349822019 @default.
- W2205934982 countsByYear W22059349822020 @default.
- W2205934982 countsByYear W22059349822021 @default.
- W2205934982 countsByYear W22059349822022 @default.
- W2205934982 countsByYear W22059349822023 @default.
- W2205934982 crossrefType "journal-article" @default.
- W2205934982 hasAuthorship W2205934982A5002450468 @default.
- W2205934982 hasAuthorship W2205934982A5003787100 @default.
- W2205934982 hasAuthorship W2205934982A5006168466 @default.
- W2205934982 hasAuthorship W2205934982A5007435283 @default.
- W2205934982 hasAuthorship W2205934982A5007604152 @default.
- W2205934982 hasAuthorship W2205934982A5015872707 @default.
- W2205934982 hasAuthorship W2205934982A5016817677 @default.
- W2205934982 hasAuthorship W2205934982A5019145198 @default.
- W2205934982 hasAuthorship W2205934982A5019722118 @default.
- W2205934982 hasAuthorship W2205934982A5034532201 @default.
- W2205934982 hasAuthorship W2205934982A5034549592 @default.
- W2205934982 hasAuthorship W2205934982A5038117448 @default.
- W2205934982 hasAuthorship W2205934982A5041063715 @default.
- W2205934982 hasAuthorship W2205934982A5044092723 @default.
- W2205934982 hasAuthorship W2205934982A5045130561 @default.