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- W2206016105 abstract "Aim: To investigate gene and protein inflammasome components expression in the liver of rats during the development of cachexia induced by Walker 256 carcinosarcoma. Methods: Eight-weeks old male rats were subcutaneously inoculated with a Walker 256 carcinosarcoma cell suspension (2 × 10 7 cells in 1.0 mL; tumour-bearing, TB) or PBS control (C). The liver was excised on days 0, 7 and 14 after tumour cell injection. Cytokine mRNA analysis was performed by real time PCR and protein content evaluated with ELISA (normalized for total protein in the samples). Results: NLR family, pyrin domain containing (Nlrp 1 and 3) gene expression was increased already on day 7 (2.1 and 3.2-fold; p p p p p p p p Conclusion: These results showed metabolism-related genes not to be able restore triacylglycerol liver during tumour progression and, in final stage of the cachexia the increased of the inflammasome components were inversely with metabolism gene, it is suggesting a modulation these gene for pathway inflammasome." @default.
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- W2206016105 date "2013-09-01" @default.
- W2206016105 modified "2023-10-17" @default.
- W2206016105 title "185" @default.
- W2206016105 doi "https://doi.org/10.1016/j.cyto.2013.06.188" @default.
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