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- W2206053562 abstract "Three experiments examined the hypoalgesia induced in rats treated with naloxone and repeatedly exposed to a heated floor. Experiment 1 revealed that a history of saline treatment with exposures to the heated floor impaired the acquisition of naloxone-stressor-induced hypoalgesia, and there was evidence that this attenuation resulted from familiarity with the heat stressor. In contrast, a history of exposures to morphine-heat-stressor pairings did not have an effect on naloxone-stressor-induced hypoalgesia, and the acquisition of this hypoalgesia did not extinguish the previously acquired tolerance to morphine hypoalgesia. Experiment 2 confirmed that the context associated with naloxone-stressor pairings provoked a conditioned hypoalgesia that sum-mates with morphine hypoalgesia. The expression of the conditioned hypoalgesia did not have an effect on the rate at which morphine hypoalgesic tolerance developed, and the acquisition of such tolerance did not extinguish naloxone-stressor-induced hypoalgesia. Experiment 3 confirmed that this failure to extinguish naloxone-stressor-induced hypoalgesia was not due to morphine’s preventing extinction of the conditioned hypoalgesia. The results were interpreted to mean that the hypoalgesia induced by naloxone-heat-stressor pairings, or by the context associated with these pairings, is mediated by nonopioid mechanisms that are distinct from those activated by morphine. The implication of the evidence for naloxone-stressor-induced hypoalgesia for the nature of the hypoalgesias conditioned by shock is discussed." @default.
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- W2206053562 title "The hypoalgesia conditioned by a heat Stressor with naloxone is nonopioid: Implications for the hypoalgesias conditioned by shock" @default.
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- W2206053562 doi "https://doi.org/10.3758/bf03327162" @default.
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