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- W2206058049 abstract "The bodily response of mammals to stressful situations is characterized by a complex pattern of behavioural, endocrine and autonomic changes (Fig. 1). A variety of these so-called “stress” indices are nowadays routinely employed as the dependent variable in animal models designed for studying the neuropharmacological mechanisms of stress/anxiety and, in particular, for evaluating the potential anti-stress or anxiolytic actions of new compounds. These include: suppressed operant behaviour (Geller & Seifter, 1960; Vogel et al., 1971), startle potentiation (Davis, 1979). decreased exploratory activity (Crawley, 1981; Meert & Colpaert, 1984; Yamamoto & Ueki, 1987), decreased social interaction (File, 1980), increased burying behaviour (Treit et al., 1981), and elevated plasma corticosteroid concentrations (Lahti & Barsuhn, 1974; Le Fur et al., 1979; Gram & Christensen; 1986). It is generally assumed that compounds with anti-stress or anxiolytic activity are characterized by their potency to inhibit or block these changes, while the ability to induce or enhance them is a reflection of anxiogenic or pro-stress properties. The usefulness and shortcomings of different animal models of stress/anxiety have been extensively reviewed by Treit (1985), and will not be discussed further in this chapter." @default.
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- W2206058049 date "1991-01-01" @default.
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- W2206058049 title "Behavioural and Hormonal Indices of Anxiolytic and Anxiogenic Drug Action in the Shock Prod Defensive Burying/Avoidance Paradigm" @default.
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- W2206058049 doi "https://doi.org/10.1007/978-3-0348-6419-0_9" @default.
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