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• W2206182044 endingPage "255" @default.
• W2206182044 startingPage "229" @default.
• W2206182044 abstract "Nitric oxide (NO) signaling plays a key role in modulating vascular tone and remodeling in the pulmonary circulation. The guanylate cyclase/cyclic guanylate monophosphate-signaling pathway primarily mediates nitric oxide signaling. This pathway is critical in normal regulation of the pulmonary vasculature, and is an important target for therapy in patients with pulmonary hypertension. In the pulmonary vasculature, degradation of cGMP is primarily regulated by PDE-5, and inhibition of this enzyme has important effects on pulmonary vasculature smooth muscle tone. Large randomized placebo-controlled trials of PDE-5 inhibitors demonstrated improved exercise capacity, hemodynamics and quality of life in adult patients with PAH. This chapter will discuss the mechanisms of NO signaling in the vasculature, characteristics of the PDE5-inhibitors approved for treatment of PH, and review available data on the use of phosphodiesterase inhibitors in PH." @default.
• W2206182044 created "2016-06-24" @default.
• W2206182044 creator A5021150751 @default.
• W2206182044 creator A5063802245 @default.
• W2206182044 date "2013-01-01" @default.
• W2206182044 modified "2023-10-02" @default.
• W2206182044 title "Phosphodiesterase-5 Inhibitors" @default.
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• W2206182044 doi "https://doi.org/10.1007/978-3-642-38664-0_10" @default.

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