FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2206571331> ?p ?o ?g. }

• W2206571331 endingPage "1247" @default.
• W2206571331 startingPage "1234" @default.
• W2206571331 abstract "Women of advanced maternal age (AMA) (age ≥ 35) have increased rates of infertility, miscarriages, and trisomic pregnancies. Collectively these conditions are called egg infertility. A root cause of egg infertility is increased rates of oocyte aneuploidy with age. AMA women often have elevated endogenous FSH. Female senescence-accelerated mouse-prone-8 (SAMP8) has increased rates of oocyte spindle aberrations, diminished fertility, and rising endogenous FSH with age. We hypothesize that elevated FSH during the oocyte's FSH-responsive growth period is a cause of abnormalities in the meiotic spindle. We report that eggs from SAMP8 mice treated with equine chorionic gonadotropin (eCG) for the period of oocyte growth have increased chromosome and spindle misalignments. Activin is a molecule that raises FSH, and ActRIIB:Fc is an activin decoy receptor that binds and sequesters activin. We report that ActRIIB:Fc treatment of midlife SAMP8 mice for the duration of oocyte growth lowers FSH, prevents egg chromosome and spindle misalignments, and increases litter sizes. AMA patients can also have poor responsiveness to FSH stimulation. We report that although eCG lowers yields of viable oocytes, ActRIIB:Fc increases yields of viable oocytes. ActRIIB:Fc and eCG cotreatment markedly reduces yields of viable oocytes. These data are consistent with the hypothesis that elevated FSH contributes to egg aneuploidy, declining fertility, and poor ovarian response and that ActRIIB:Fc can prevent egg aneuploidy, increase fertility, and improve ovarian response. Future studies will continue to examine whether ActRIIB:Fc works via FSH and/or other pathways and whether ActRIIB:Fc can prevent aneuploidy, increase fertility, and improve stimulation responsiveness in AMA women." @default.
• W2206571331 created "2016-06-24" @default.
• W2206571331 creator A5002829719 @default.
• W2206571331 creator A5006493859 @default.
• W2206571331 creator A5039280689 @default.
• W2206571331 creator A5059458064 @default.
• W2206571331 creator A5084402133 @default.
• W2206571331 date "2015-12-29" @default.
• W2206571331 modified "2023-10-16" @default.
• W2206571331 title "Activin Decoy Receptor ActRIIB:Fc Lowers FSH and Therapeutically Restores Oocyte Yield, Prevents Oocyte Chromosome Misalignments and Spindle Aberrations, and Increases Fertility in Midlife Female SAMP8 Mice" @default.
• W2206571331 cites W1505936575 @default.
• W2206571331 cites W1939946825 @default.
• W2206571331 cites W1964218535 @default.
• W2206571331 cites W1964735970 @default.
• W2206571331 cites W1965230064 @default.
• W2206571331 cites W1966713508 @default.
• W2206571331 cites W1968729713 @default.
• W2206571331 cites W1971189666 @default.
• W2206571331 cites W1977151351 @default.
• W2206571331 cites W1978691222 @default.
• W2206571331 cites W1987092404 @default.
• W2206571331 cites W1991877215 @default.
• W2206571331 cites W1995586478 @default.
• W2206571331 cites W2000526660 @default.
• W2206571331 cites W2012215090 @default.
• W2206571331 cites W2013003881 @default.
• W2206571331 cites W2013378554 @default.
• W2206571331 cites W2013398381 @default.
• W2206571331 cites W2013587336 @default.
• W2206571331 cites W2013831977 @default.
• W2206571331 cites W2015010970 @default.
• W2206571331 cites W2016128965 @default.
• W2206571331 cites W2016514310 @default.
• W2206571331 cites W2020516054 @default.
• W2206571331 cites W2024226340 @default.
• W2206571331 cites W2029716263 @default.
• W2206571331 cites W2041647799 @default.
• W2206571331 cites W2041759950 @default.
• W2206571331 cites W2042670148 @default.
• W2206571331 cites W2046709897 @default.
• W2206571331 cites W2048140564 @default.
• W2206571331 cites W2049166996 @default.
• W2206571331 cites W2055928729 @default.
• W2206571331 cites W2058843560 @default.
• W2206571331 cites W2059499274 @default.
• W2206571331 cites W2061320431 @default.
• W2206571331 cites W2062368760 @default.
• W2206571331 cites W2065266869 @default.
• W2206571331 cites W2070566521 @default.
• W2206571331 cites W2070808285 @default.
• W2206571331 cites W2071252135 @default.
• W2206571331 cites W2071484008 @default.
• W2206571331 cites W2074746487 @default.
• W2206571331 cites W2080700340 @default.
• W2206571331 cites W2084900054 @default.
• W2206571331 cites W2085723458 @default.
• W2206571331 cites W2092224562 @default.
• W2206571331 cites W2094746916 @default.
• W2206571331 cites W2097956462 @default.
• W2206571331 cites W2098421386 @default.
• W2206571331 cites W2101472329 @default.
• W2206571331 cites W2104589194 @default.
• W2206571331 cites W2105262699 @default.
• W2206571331 cites W2105838724 @default.
• W2206571331 cites W2107610145 @default.
• W2206571331 cites W2108784746 @default.
• W2206571331 cites W2110691960 @default.
• W2206571331 cites W2113019038 @default.
• W2206571331 cites W2113550031 @default.
• W2206571331 cites W2114066459 @default.
• W2206571331 cites W2114634093 @default.
• W2206571331 cites W2117470501 @default.
• W2206571331 cites W2119072373 @default.
• W2206571331 cites W2119889599 @default.
• W2206571331 cites W2121336593 @default.
• W2206571331 cites W2121361131 @default.
• W2206571331 cites W2122484354 @default.
• W2206571331 cites W2123992950 @default.
• W2206571331 cites W2127096630 @default.
• W2206571331 cites W2129623694 @default.
• W2206571331 cites W2131051775 @default.
• W2206571331 cites W2131156853 @default.
• W2206571331 cites W2131644540 @default.
• W2206571331 cites W2134101078 @default.
• W2206571331 cites W2134692744 @default.
• W2206571331 cites W2140372014 @default.
• W2206571331 cites W2142521196 @default.
• W2206571331 cites W2142885851 @default.
• W2206571331 cites W2144724725 @default.
• W2206571331 cites W2146115265 @default.
• W2206571331 cites W2146614764 @default.
• W2206571331 cites W2146673094 @default.
• W2206571331 cites W2147345056 @default.
• W2206571331 cites W2148455133 @default.
• W2206571331 cites W2149993139 @default.
• W2206571331 cites W2151283204 @default.
• W2206571331 cites W2155111691 @default.
• W2206571331 cites W2157999278 @default.

• next