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- W2206732072 abstract "The pharmacokinetics of 3-keto-desogestrel and ethinyl estradiol (EE) and the safety of Org5187 (150 mcg desogestrel and 30 mcg EE) in 17 healthy Japanese women (single dose--8, multiple dose--9) were studied after oral administration. After single dose administration, Tmax, Cmax elimination 1/2 life (t1/2beta), and the area under the curve (AUC) of 3-keto-desogestrel were 1.8 +or- 0, 7 hour; 3.9 +or- 1.36 pmol/ml, 19.1 +or- 13.0 hours; and 28.6 +or- 22.9 pmol h/ml, respectively. On the other hand, those after multiple dose were 1.2 +or- 0.6 hour (Tmax), 12.12 +or- 5.49 pmol/ml (Cmax), 22.0 +or- 9.6 hour (t1/2beta), and 97.2 +or- 36.8 pmol h/ml (AUC), respectively. Pharmacokinetic parameters of EE were 1.69 +or- ), 96 hour (Tmax), 0.638 +or-0.025 pmol/ml (Cmax), 20.0 +or- 12.3 hour (t1/2beta), and 7.0 +or- 4.12 pmol h/ml (AUC) after single dose, and 1.11 +or- 0.5 (Tmax), 1.180 +or- 0, 315 pmol/ml (Cmax), 23.7 +or- 8.8 hour (t1/2beta), 11.7 +or- 3, 3pmol h/ml (AUC) after multiple dose. The serum concentrations of 3-keto-desogestrel and EE reached a steady state on the 15th day after initiating administration. No differences were observed between Japanese and European female volunteers in the pharmacokinetics of 3-keto-desogestrel and EE. During the period of multiple dose treatment, neither irregular bleedings nor side effects leading to dropouts were observed. (author's)" @default.
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- W2206732072 date "1991-01-01" @default.
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- W2206732072 title "[Clinical pharmacokinetic study of Org5187 as a low-dose oral contraceptive]." @default.
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