FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2206858963> ?p ?o ?g. }

• W2206858963 endingPage "3330" @default.
• W2206858963 startingPage "3322" @default.
• W2206858963 abstract "Safety precautions for laboratory staff working with meningococci should primarily rely on laboratory procedures preventing exposure to aerosols containing viable meningococci. Despite this, vaccination is a key component of protection in the occupational setting. In the UK in 2009, there were no licensed vaccines for meningococcal capsular group B or conjugate vaccines for capsular groups A, C, W and Y. We therefore undertook a Phase II trial in laboratory workers to investigate the safety and immunogenicity of a four component group B vaccine (4CMenB) and a quadrivalent group A, C, W and Y conjugate vaccine (ACWY-CRM). Enrolment was open to staff aged 18-65 years at the Public Health Laboratory, Manchester who may have had a potential occupational exposure risk to meningococci. 4CMenB was administered at 0, 2 and 6 months in the non-dominant arm and ACWY-CRM concomitantly at 0 months in the dominant arm. Pre- and post-vaccination blood samples were taken and analysed by the serum bactericidal antibody (SBA) assay against A, C, W and Y strains and a panel of seven diverse group B strains. Diary cards were used to record any local and systemic reactions following each vaccination. In total, 38 staff were enrolled and received initial vaccinations with 31 completing the trial per protocol. Both vaccines were proven safe, with local reactogenicity being more commonly reported following 4CMenB than ACWY-CRM. High proportions of subjects had putative protective SBA titres pre-vaccination, with 61-84 and 61-87% protected against A, C, W and Y strains and diverse MenB strains, respectively. Post-vaccination, SBA titres increased with 95-100 and 90-100% of subjects with protective SBA titres against A, C, W and Y strains and diverse MenB strains, respectively. These data suggest that 4CMenB and ACWY-CRM are safe when administered concomitantly and have the potential to enhance protection for laboratory workers. www.clinicaltrials.gov identifier: NCT00962624." @default.
• W2206858963 created "2016-06-24" @default.
• W2206858963 creator A5016743366 @default.
• W2206858963 creator A5047481687 @default.
• W2206858963 creator A5050450991 @default.
• W2206858963 creator A5053121427 @default.
• W2206858963 creator A5054039682 @default.
• W2206858963 creator A5066337330 @default.
• W2206858963 creator A5078694961 @default.
• W2206858963 date "2015-06-01" @default.
• W2206858963 modified "2023-10-16" @default.
• W2206858963 title "Safety and immunogenicity of a four-component meningococcal group B vaccine (4CMenB) and a quadrivalent meningococcal group ACWY conjugate vaccine administered concomitantly in healthy laboratory workers" @default.
• W2206858963 cites W1494431169 @default.
• W2206858963 cites W1838881035 @default.
• W2206858963 cites W1943307706 @default.
• W2206858963 cites W1964837397 @default.
• W2206858963 cites W1965928921 @default.
• W2206858963 cites W1985306230 @default.
• W2206858963 cites W2004976172 @default.
• W2206858963 cites W2030879365 @default.
• W2206858963 cites W2031757380 @default.
• W2206858963 cites W2046267384 @default.
• W2206858963 cites W2048066073 @default.
• W2206858963 cites W2053122126 @default.
• W2206858963 cites W2077837450 @default.
• W2206858963 cites W2097124616 @default.
• W2206858963 cites W2098499618 @default.
• W2206858963 cites W2111315524 @default.
• W2206858963 cites W2115350923 @default.
• W2206858963 cites W2118976076 @default.
• W2206858963 cites W2122656158 @default.
• W2206858963 cites W2124041811 @default.
• W2206858963 cites W2126522298 @default.
• W2206858963 cites W2128589740 @default.
• W2206858963 cites W2130460485 @default.
• W2206858963 cites W2135324528 @default.
• W2206858963 cites W2137543705 @default.
• W2206858963 cites W2143988742 @default.
• W2206858963 cites W2144354156 @default.
• W2206858963 cites W2147483877 @default.
• W2206858963 cites W2151309008 @default.
• W2206858963 cites W2151862050 @default.
• W2206858963 cites W2151895962 @default.
• W2206858963 cites W2157295868 @default.
• W2206858963 cites W2164471333 @default.
• W2206858963 cites W2171902734 @default.
• W2206858963 doi "https://doi.org/10.1016/j.vaccine.2015.05.027" @default.
• W2206858963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26025807" @default.
• W2206858963 hasPublicationYear "2015" @default.
• W2206858963 type Work @default.
• W2206858963 sameAs 2206858963 @default.
• W2206858963 citedByCount "31" @default.
• W2206858963 countsByYear W22068589632015 @default.
• W2206858963 countsByYear W22068589632016 @default.
• W2206858963 countsByYear W22068589632017 @default.
• W2206858963 countsByYear W22068589632018 @default.
• W2206858963 countsByYear W22068589632019 @default.
• W2206858963 countsByYear W22068589632020 @default.
• W2206858963 countsByYear W22068589632021 @default.
• W2206858963 countsByYear W22068589632022 @default.
• W2206858963 countsByYear W22068589632023 @default.
• W2206858963 crossrefType "journal-article" @default.
• W2206858963 hasAuthorship W2206858963A5016743366 @default.
• W2206858963 hasAuthorship W2206858963A5047481687 @default.
• W2206858963 hasAuthorship W2206858963A5050450991 @default.
• W2206858963 hasAuthorship W2206858963A5053121427 @default.
• W2206858963 hasAuthorship W2206858963A5054039682 @default.
• W2206858963 hasAuthorship W2206858963A5066337330 @default.
• W2206858963 hasAuthorship W2206858963A5078694961 @default.
• W2206858963 hasConcept C126322002 @default.
• W2206858963 hasConcept C159654299 @default.
• W2206858963 hasConcept C203014093 @default.
• W2206858963 hasConcept C22070199 @default.
• W2206858963 hasConcept C2776645655 @default.
• W2206858963 hasConcept C2777704310 @default.
• W2206858963 hasConcept C2777785397 @default.
• W2206858963 hasConcept C2778458888 @default.
• W2206858963 hasConcept C2779583294 @default.
• W2206858963 hasConcept C2780454893 @default.
• W2206858963 hasConcept C2780678043 @default.
• W2206858963 hasConcept C2780801004 @default.
• W2206858963 hasConcept C2780868878 @default.
• W2206858963 hasConcept C523546767 @default.
• W2206858963 hasConcept C54355233 @default.
• W2206858963 hasConcept C71924100 @default.
• W2206858963 hasConcept C86803240 @default.
• W2206858963 hasConceptScore W2206858963C126322002 @default.
• W2206858963 hasConceptScore W2206858963C159654299 @default.
• W2206858963 hasConceptScore W2206858963C203014093 @default.
• W2206858963 hasConceptScore W2206858963C22070199 @default.
• W2206858963 hasConceptScore W2206858963C2776645655 @default.
• W2206858963 hasConceptScore W2206858963C2777704310 @default.
• W2206858963 hasConceptScore W2206858963C2777785397 @default.
• W2206858963 hasConceptScore W2206858963C2778458888 @default.
• W2206858963 hasConceptScore W2206858963C2779583294 @default.
• W2206858963 hasConceptScore W2206858963C2780454893 @default.
• W2206858963 hasConceptScore W2206858963C2780678043 @default.
• W2206858963 hasConceptScore W2206858963C2780801004 @default.

• next