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• W2206899420 startingPage "347" @default.
• W2206899420 abstract "Second-line, salvage chemotherapy followed by high-dose chemotherapy and autologous stem cell transplantation (AUTO-SCT) is the standard of care for patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL). Approximately 50% of patients relapse after AUTO-SCT and their prognosis is generally poor. Brentuximab Vedotin (BV) has demonstrated efficacy in this setting and allogeneic (ALLO)-SCT represents an option with curative potential in this subgroup of patients.A systematic review has been conducted to explore the actual knowledge on ALLO-SCT, BV and newer agents in R/R HL.The introduction of BV in clinical practice has significantly improved the management of post-AUTO-SCT relapses and the drug can induce durable remissions in a subset of R/R HL. Allografting select patients has been used to improve clinical outcomes and recent case series have begun to explore BV as a potential 'bridge' to allo-SCT, even though the optimal timing of ALLO-SCT after BV response remains undetermined. However, reduced tumor burden at the time of ALLO-SCT is a key factor to decrease relapse risk. Based on the unique composition of the tumor, more recently new agents such as PD-1 inhibitors have been developed. The potential role of PD-1 inhibitors with ALLO-SCT remains to be explored." @default.
• W2206899420 created "2016-06-24" @default.
• W2206899420 creator A5001406717 @default.
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• W2206899420 creator A5077505240 @default.
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• W2206899420 creator A5086116060 @default.
• W2206899420 date "2016-02-06" @default.
• W2206899420 modified "2023-09-22" @default.
• W2206899420 title "Salvage treatment for relapsed/refractory Hodgkin lymphoma: role of allografting, brentuximab vedotin and newer agents" @default.
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