Matches in SemOpenAlex for { <https://semopenalex.org/work/W2206926146> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2206926146 endingPage "57" @default.
- W2206926146 startingPage "146" @default.
- W2206926146 abstract "To compare accelerated hypofractionated (A-HYPO) radiotherapy (RT) with conventionally fractionated (CF) thoracic RT in patients with limited-disease small-cell lung cancer (LD-SCLC).Out of 217 consecutive LD-SCLC patients, treated between 1997 and 2012, 82 received CF-RT (44-60 Gy, 2 Gy/ fraction) sequentially to 4-6 cycles of platinum-based chemotherapy (CHT), and 100 received A-HYPO-RT (42 Gy, 2.8 Gy/ fraction). Forty-two patients (42%) received early (before the 3rd cycle of CHT) A-HYPO-RT, and 58 (58%) patients received late A-HYPO-RT. Overall survival (OS), locoregional failure risk (LRFR) and toxicities were retrospectively evaluated and compared between CF-RT and A-HYPO-RT groups (also separately for early and late A-HYPO-RT).Median survival times (MST) for CF-RT and A-HYPO-RT were 18 and 24 months, respectively; 3-year OS were 19.1 and 39.4%, respectively (p=0.004). Three-year LRFR in CF-RT was 47.3% and 34.0% in the A-HYPO- RT group (p=0.12). Statistically significant difference in OS (p=0.007) and LRFR (p=0.03) was observed, favoring early A-HYPO-RT (MST=27 months, 3-year OS=40.0%, 3-year LRFR=28.4%) over CF-RT. Use of CF-RT (relative risk/RR=1.65, p=0.02) and poor CHT compliance (RR=1.69, p=0.03) were independent prognostic factors for poor OS; early start of RT was a favorable although non-significant prognostic factor for LRFR (RR=0.42, p=0.05). No difference in toxicities was observed between the groups.A-HYPO-RT results in better outcomes than CF-RT. Early A-HYPO-RT provides additional benefit in locoregional control and survival, without increased toxicity. These results indicate the need for a randomized study on the efficacy of A-HYPO-RT." @default.
- W2206926146 created "2016-06-24" @default.
- W2206926146 creator A5007051064 @default.
- W2206926146 creator A5014413652 @default.
- W2206926146 creator A5037876469 @default.
- W2206926146 creator A5044319916 @default.
- W2206926146 creator A5052025971 @default.
- W2206926146 creator A5065371133 @default.
- W2206926146 creator A5083662358 @default.
- W2206926146 date "2015-03-18" @default.
- W2206926146 modified "2023-10-18" @default.
- W2206926146 title "Accelerated hypofractionated thoracic radiotherapy in limited disease small cell lung cancer : comparison with the results of conventionally fractionated radiotherapy." @default.
- W2206926146 cites W1755201419 @default.
- W2206926146 cites W1885320430 @default.
- W2206926146 cites W1898381946 @default.
- W2206926146 cites W1918962731 @default.
- W2206926146 cites W1961685780 @default.
- W2206926146 cites W1978074676 @default.
- W2206926146 cites W1995634658 @default.
- W2206926146 cites W2004764331 @default.
- W2206926146 cites W2011868684 @default.
- W2206926146 cites W2013136834 @default.
- W2206926146 cites W2021987821 @default.
- W2206926146 cites W2040211532 @default.
- W2206926146 cites W2045359677 @default.
- W2206926146 cites W2049426090 @default.
- W2206926146 cites W2049549758 @default.
- W2206926146 cites W2056631765 @default.
- W2206926146 cites W2075954920 @default.
- W2206926146 cites W2078709072 @default.
- W2206926146 cites W2082076767 @default.
- W2206926146 cites W2084063756 @default.
- W2206926146 cites W2085223884 @default.
- W2206926146 cites W2089609590 @default.
- W2206926146 cites W2124353451 @default.
- W2206926146 cites W2125430981 @default.
- W2206926146 cites W2127093828 @default.
- W2206926146 cites W2138685162 @default.
- W2206926146 cites W2150841120 @default.
- W2206926146 cites W2160012348 @default.
- W2206926146 cites W2169848988 @default.
- W2206926146 cites W2216166526 @default.
- W2206926146 cites W2263690797 @default.
- W2206926146 cites W2321536912 @default.
- W2206926146 cites W2323020638 @default.
- W2206926146 cites W2616059838 @default.
- W2206926146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25778310" @default.
- W2206926146 hasPublicationYear "2015" @default.
- W2206926146 type Work @default.
- W2206926146 sameAs 2206926146 @default.
- W2206926146 citedByCount "5" @default.
- W2206926146 countsByYear W22069261462022 @default.
- W2206926146 countsByYear W22069261462023 @default.
- W2206926146 crossrefType "journal-article" @default.
- W2206926146 hasAuthorship W2206926146A5007051064 @default.
- W2206926146 hasAuthorship W2206926146A5014413652 @default.
- W2206926146 hasAuthorship W2206926146A5037876469 @default.
- W2206926146 hasAuthorship W2206926146A5044319916 @default.
- W2206926146 hasAuthorship W2206926146A5052025971 @default.
- W2206926146 hasAuthorship W2206926146A5065371133 @default.
- W2206926146 hasAuthorship W2206926146A5083662358 @default.
- W2206926146 hasConcept C126322002 @default.
- W2206926146 hasConcept C2776256026 @default.
- W2206926146 hasConcept C2776694085 @default.
- W2206926146 hasConcept C509974204 @default.
- W2206926146 hasConcept C71924100 @default.
- W2206926146 hasConcept C90924648 @default.
- W2206926146 hasConceptScore W2206926146C126322002 @default.
- W2206926146 hasConceptScore W2206926146C2776256026 @default.
- W2206926146 hasConceptScore W2206926146C2776694085 @default.
- W2206926146 hasConceptScore W2206926146C509974204 @default.
- W2206926146 hasConceptScore W2206926146C71924100 @default.
- W2206926146 hasConceptScore W2206926146C90924648 @default.
- W2206926146 hasIssue "1" @default.
- W2206926146 hasLocation W22069261461 @default.
- W2206926146 hasOpenAccess W2206926146 @default.
- W2206926146 hasPrimaryLocation W22069261461 @default.
- W2206926146 hasRelatedWork W2277416945 @default.
- W2206926146 hasRelatedWork W2357406576 @default.
- W2206926146 hasRelatedWork W2360529269 @default.
- W2206926146 hasRelatedWork W2378022161 @default.
- W2206926146 hasRelatedWork W2380658010 @default.
- W2206926146 hasRelatedWork W2389930763 @default.
- W2206926146 hasRelatedWork W2394006323 @default.
- W2206926146 hasRelatedWork W2407189953 @default.
- W2206926146 hasRelatedWork W2418514417 @default.
- W2206926146 hasRelatedWork W1899415052 @default.
- W2206926146 hasVolume "20" @default.
- W2206926146 isParatext "false" @default.
- W2206926146 isRetracted "false" @default.
- W2206926146 magId "2206926146" @default.
- W2206926146 workType "article" @default.