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• W2206963491 abstract "While uncommon in most of the world, nasopharyngeal carcinoma (NPC) shows an unusual geographic and ethnic distribution, being highly prevalent in Southern China and Southeast Asia. Genetic susceptibility, Epstein-Barr virus (EBV) infection and additional environmental exposures are well established risk factors for NPC in endemic areas. However, the detailed molecular mechanisms of NPC pathogenesis remain largely unknown. In this thesis, several novel pathogenic mechanisms of NPC development and progression are presented. The interaction of EBV encoded latent membrane protein 2A (LMP2A) with cellular proteins promoting invasiveness of NPC cells is described in paper I. Spleen tyrosine kinase (Syk) interacts with integrin β4 subunit (ITGβ4) in epithelial cells through an ITAMlike motif, and concurrent LMP2A expression interferes with this interaction by competitive binding to Syk. Both Syk and LMP2A affect cell surface expression of ITGβ4. Particularly, ITGβ4 concentrates at cellular protrusions in LMP2A expressing cells, which may contribute to the migration property of NPC-cells. Paper II and paper III focus on the epigenetic alteration of candidate tumor suppressor genes (TSGs) and their possible role in NPC tumorigenesis. Cadherin 4 (CDH4) and ubiquitin-conjugating enzyme 2L6 (UBE2L6) are downregulated due to promoter hypermehtylation in NPC. Both genes suppress the proliferation and colony formation of NPC-cells. CDH4 impedes cell migration and elicits cell communication; UBE2L6 induce apoptosis of NPC cells and counteracts degradation of adipocyte triglyceride lipase (ATGL) through ISG15-conjugation of valosin-containing protein (VCP). CDH4 and UBE2L6 could be involved in both initiation and progression of NPC. Suppression of UBE2L6 encoded protein UbcH8 correlated with poor outcome in NPC patients. In paper IV, we compared the response of NPC and normal nasopharyngeal epithelial (NNE) cell lines to bacteria and bacterial cell wall components. Strong nuclear translocation of NF-κB and significant induction of proinflammatory factors IL6, IL8, IL1α and CXCL2 were observed in NNE cells, but not in NPC cells upon exposure to Gram-positive bacteria streptococci and peptidoglycan (PGN). We identified three different mechanisms by which the activation of NF-κB in NPC cells could be hampered. It could be trapped by an enhanced accumulation of cytoplasmic lipids. I-κB degradation could be impaired due to downregulation of UBE2L6. We also showed that overexpression of lysine-specific demethylase-1 (LSD1) blocked the transcriptional activation of proinflammatory genes. Together these mechanisms might contribute to decreased immune reactivity in NPC and thus affect tumor progression. LIST OF SCIENTIFIC PAPERS I. Xiao-Ying Zhou#, Liudmila Matskova#, Li-Sophie Z. Rathje#, Xue Xiao, Gerald Gish, Maria Werner, Ilya Ignatyev, Na-Na Yu, Wei-Lin Zhao, Fang-Yun Tian, Bo Hou, Zhe Zhang, Tony Pawson, Fu Chen, Ingemar Ernberg*, SYK interaction with ITGβ4 suppressed by Epstein-Barr Virus LMP2A modulates migration and invasion of Nasopharyngeal Carcinoma Cells. Oncogene. 2015 Aug 20;34(34):4491-4499. PMID: 25531330 II. Chun-Ping Du#, Ting-Ting Huang#, Di Sun, Ying-Xi Mo, Hai-Yan Feng, Xiao-Ying Zhou, Xue Xiao, Na-Na Yu, Bo Hou, Guang-Wu Huang, Ingemar Ernberg, Zhe Zhang*, CDH4 as a novel putative tumor suppressor gene epigenetically silenced by promoter hypermethylation in nasopharyngeal carcinoma. Cancer Lett. 2011 Oct 1; 309 (1):54-61. PMID: 21665361 III. Xiao-Ying Zhou#, Jia-Zhang Wei#, Fu Chen, Xue Xiao, Ting-Ting Huang, Qian He, Shu-Min Wang, Chun-Ping Du, Ying-Xi Mo, Long-De Lin, Ying Xie, Li-Li Wei, Ying Lan, Mairiko Murata, Guang-Wu Huang, Ingemar Ernberg*, Liudmila Matskova, Zhe Zhang*, Epigenetic downregulation of the ISG15-conjugating enzyme UbcH8 impairs lipolysis and correlates with poor prognosis in nasopharyngeal carcinoma. Oncotarget, in press. IV. Xiao-Ying Zhou, Liudmila Matskova, Xue Xiao, Yu-Feng Chen, Feng He, GuangWu Huang, Zhe Zhang, Ingemar Ernberg*, Induction of inflammatory response in nasopharyngeal epithelial cells by microflora components is impaired in nasopharyngeal carcinoma cells. Manuscript. # These authors contributed equally as first authors. *Corresponding author" @default.
• W2206963491 created "2016-06-24" @default.
• W2206963491 creator A5089110764 @default.
• W2206963491 date "2015-10-19" @default.
• W2206963491 modified "2023-09-27" @default.
• W2206963491 title "Microbial and epigenetic factors in the pathogenesis of nasopharyngeal carcinoma" @default.
• W2206963491 cites W1094547483 @default.
• W2206963491 cites W127317704 @default.
• W2206963491 cites W1485543117 @default.
• W2206963491 cites W1488792046 @default.
• W2206963491 cites W1491641153 @default.
• W2206963491 cites W1502521980 @default.
• W2206963491 cites W1512808775 @default.
• W2206963491 cites W1516920003 @default.
• W2206963491 cites W1570988662 @default.
• W2206963491 cites W1578954095 @default.
• W2206963491 cites W1581034919 @default.
• W2206963491 cites W1588125282 @default.
• W2206963491 cites W1593352795 @default.
• W2206963491 cites W1596095139 @default.
• W2206963491 cites W1605704109 @default.
• W2206963491 cites W1613120244 @default.
• W2206963491 cites W1619287162 @default.
• W2206963491 cites W1620160353 @default.
• W2206963491 cites W1646424808 @default.
• W2206963491 cites W1648351485 @default.
• W2206963491 cites W1658465453 @default.
• W2206963491 cites W1726030378 @default.
• W2206963491 cites W1759376742 @default.
• W2206963491 cites W1762734860 @default.
• W2206963491 cites W1769839833 @default.
• W2206963491 cites W1775309324 @default.
• W2206963491 cites W1823309428 @default.
• W2206963491 cites W1834684878 @default.
• W2206963491 cites W1905915630 @default.
• W2206963491 cites W1911905720 @default.
• W2206963491 cites W1917664866 @default.
• W2206963491 cites W1923045889 @default.
• W2206963491 cites W1931073059 @default.
• W2206963491 cites W1941566493 @default.
• W2206963491 cites W1965037168 @default.
• W2206963491 cites W1965075196 @default.
• W2206963491 cites W1965938570 @default.
• W2206963491 cites W1968075505 @default.
• W2206963491 cites W1968260614 @default.
• W2206963491 cites W1968540478 @default.
• W2206963491 cites W1971843379 @default.
• W2206963491 cites W1972583619 @default.
• W2206963491 cites W1972731560 @default.
• W2206963491 cites W1975229775 @default.
• W2206963491 cites W1976607903 @default.
• W2206963491 cites W1976888905 @default.
• W2206963491 cites W1982981861 @default.
• W2206963491 cites W1983162429 @default.
• W2206963491 cites W1983565994 @default.
• W2206963491 cites W1984710154 @default.
• W2206963491 cites W1985100272 @default.
• W2206963491 cites W1987589884 @default.
• W2206963491 cites W1988476050 @default.
• W2206963491 cites W1991646228 @default.
• W2206963491 cites W1993328555 @default.
• W2206963491 cites W1993487805 @default.
• W2206963491 cites W1994604625 @default.
• W2206963491 cites W1995334258 @default.
• W2206963491 cites W1996118868 @default.
• W2206963491 cites W1996127398 @default.
• W2206963491 cites W1999841187 @default.
• W2206963491 cites W2002232196 @default.
• W2206963491 cites W2003545535 @default.
• W2206963491 cites W2003900547 @default.
• W2206963491 cites W2004333326 @default.
• W2206963491 cites W2005049291 @default.
• W2206963491 cites W2005682191 @default.
• W2206963491 cites W2006292369 @default.
• W2206963491 cites W2008044453 @default.
• W2206963491 cites W2009756591 @default.
• W2206963491 cites W2010141265 @default.
• W2206963491 cites W2010180276 @default.
• W2206963491 cites W2012913175 @default.
• W2206963491 cites W2014058353 @default.
• W2206963491 cites W2014718627 @default.
• W2206963491 cites W2016491103 @default.
• W2206963491 cites W2018972429 @default.
• W2206963491 cites W2020830322 @default.
• W2206963491 cites W2022030111 @default.
• W2206963491 cites W2022839080 @default.
• W2206963491 cites W2023164440 @default.
• W2206963491 cites W2023218744 @default.
• W2206963491 cites W2023452119 @default.
• W2206963491 cites W2023754542 @default.
• W2206963491 cites W2024244209 @default.
• W2206963491 cites W2024315171 @default.
• W2206963491 cites W2024954553 @default.
• W2206963491 cites W2028544780 @default.
• W2206963491 cites W2029142939 @default.
• W2206963491 cites W2029533522 @default.
• W2206963491 cites W2029868343 @default.
• W2206963491 cites W2030864103 @default.
• W2206963491 cites W2032375096 @default.
• W2206963491 cites W2032918000 @default.

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