Matches in SemOpenAlex for { <https://semopenalex.org/work/W2207051257> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2207051257 endingPage "123.7" @default.
- W2207051257 startingPage "123.7" @default.
- W2207051257 abstract "Abstract The human low affinity IgE receptor, CD23 (FceRII), is capable of transporting IgE or IgE-allergen complexes across the polarized human airway epithelial cell (AEC) monolayer in vitro. However, it remains completely unknown whether CD23-dependent IgE transfer pathway in AECs initiates and facilitates allergic inflammation in vivo. To prove this, we first showed that epithelial CD23 in wild-type (WT) mice transcytosed either IgE or ovalbumin (OVA)-IgE complexes across the airway epithelial barrier. Neither type of transcytosis was observed in CD23-knockout (KO) mice. The OVA sensitization and aerosol challenge of the irradiated WT/WT or CD23KO/WT chimeric mice that CD23 expressed on radioresistant airway structural cells, mainly in epithelial cells, resulted in airway eosinophilia, lung damages including collagen deposition and significantly increased goblet cells, and increased airways hyperreactivity. In contrast, the absence of CD23 expression on airway structural or epithelial cells, but not on hematopoietic cells, of the bone-marrow chimeric mice (WT/CD23KO) significantly reduced OVA-driven allergic airway inflammation. Finally inhalation of a CD23-blocking B3B4 antibody to target exposed CD23 in AECs of the sensitized WT mice before airway challenge suppressed the salient features of asthma, including bronchial hyperreactivity. Our study further suggests that the functional inhibition of CD23 on AECs is a potential therapeutic means to intervene the asthma development." @default.
- W2207051257 created "2016-06-24" @default.
- W2207051257 creator A5000753254 @default.
- W2207051257 creator A5001825800 @default.
- W2207051257 creator A5014906789 @default.
- W2207051257 creator A5021827662 @default.
- W2207051257 creator A5051256823 @default.
- W2207051257 creator A5051725827 @default.
- W2207051257 creator A5068930868 @default.
- W2207051257 creator A5069164357 @default.
- W2207051257 creator A5075045337 @default.
- W2207051257 creator A5082358747 @default.
- W2207051257 creator A5088656181 @default.
- W2207051257 date "2015-05-01" @default.
- W2207051257 modified "2023-09-25" @default.
- W2207051257 title "Inhibition of CD23-mediated IgE transcytosis suppresses the initiation and development of airway allergic inflammation (HYP4P.308)" @default.
- W2207051257 doi "https://doi.org/10.4049/jimmunol.194.supp.123.7" @default.
- W2207051257 hasPublicationYear "2015" @default.
- W2207051257 type Work @default.
- W2207051257 sameAs 2207051257 @default.
- W2207051257 citedByCount "1" @default.
- W2207051257 countsByYear W22070512572023 @default.
- W2207051257 crossrefType "journal-article" @default.
- W2207051257 hasAuthorship W2207051257A5000753254 @default.
- W2207051257 hasAuthorship W2207051257A5001825800 @default.
- W2207051257 hasAuthorship W2207051257A5014906789 @default.
- W2207051257 hasAuthorship W2207051257A5021827662 @default.
- W2207051257 hasAuthorship W2207051257A5051256823 @default.
- W2207051257 hasAuthorship W2207051257A5051725827 @default.
- W2207051257 hasAuthorship W2207051257A5068930868 @default.
- W2207051257 hasAuthorship W2207051257A5069164357 @default.
- W2207051257 hasAuthorship W2207051257A5075045337 @default.
- W2207051257 hasAuthorship W2207051257A5082358747 @default.
- W2207051257 hasAuthorship W2207051257A5088656181 @default.
- W2207051257 hasConcept C126322002 @default.
- W2207051257 hasConcept C141105273 @default.
- W2207051257 hasConcept C147483822 @default.
- W2207051257 hasConcept C159654299 @default.
- W2207051257 hasConcept C170493617 @default.
- W2207051257 hasConcept C185350488 @default.
- W2207051257 hasConcept C203014093 @default.
- W2207051257 hasConcept C2776217527 @default.
- W2207051257 hasConcept C2776914184 @default.
- W2207051257 hasConcept C2776946954 @default.
- W2207051257 hasConcept C2779675166 @default.
- W2207051257 hasConcept C28005876 @default.
- W2207051257 hasConcept C34814297 @default.
- W2207051257 hasConcept C71924100 @default.
- W2207051257 hasConceptScore W2207051257C126322002 @default.
- W2207051257 hasConceptScore W2207051257C141105273 @default.
- W2207051257 hasConceptScore W2207051257C147483822 @default.
- W2207051257 hasConceptScore W2207051257C159654299 @default.
- W2207051257 hasConceptScore W2207051257C170493617 @default.
- W2207051257 hasConceptScore W2207051257C185350488 @default.
- W2207051257 hasConceptScore W2207051257C203014093 @default.
- W2207051257 hasConceptScore W2207051257C2776217527 @default.
- W2207051257 hasConceptScore W2207051257C2776914184 @default.
- W2207051257 hasConceptScore W2207051257C2776946954 @default.
- W2207051257 hasConceptScore W2207051257C2779675166 @default.
- W2207051257 hasConceptScore W2207051257C28005876 @default.
- W2207051257 hasConceptScore W2207051257C34814297 @default.
- W2207051257 hasConceptScore W2207051257C71924100 @default.
- W2207051257 hasIssue "1_Supplement" @default.
- W2207051257 hasLocation W22070512571 @default.
- W2207051257 hasOpenAccess W2207051257 @default.
- W2207051257 hasPrimaryLocation W22070512571 @default.
- W2207051257 hasRelatedWork W1975173921 @default.
- W2207051257 hasRelatedWork W1975985310 @default.
- W2207051257 hasRelatedWork W1981629998 @default.
- W2207051257 hasRelatedWork W1997877825 @default.
- W2207051257 hasRelatedWork W2004145744 @default.
- W2207051257 hasRelatedWork W2029245561 @default.
- W2207051257 hasRelatedWork W2099512139 @default.
- W2207051257 hasRelatedWork W2415872318 @default.
- W2207051257 hasRelatedWork W2562974677 @default.
- W2207051257 hasRelatedWork W3212012594 @default.
- W2207051257 hasVolume "194" @default.
- W2207051257 isParatext "false" @default.
- W2207051257 isRetracted "false" @default.
- W2207051257 magId "2207051257" @default.
- W2207051257 workType "article" @default.