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- W2207128690 abstract "Perioperative decolonization of Staphylococcus aureus nasal carriers with mupirocin together with chlorhexidine body washing reduces the incidence of S. aureus surgical site infection. A targeted strategy, applied in S. aureus carriers only, is costly, and implementation may reduce effectiveness. Universal decolonization is more cost-effective but increases exposure of noncarriers to mupirocin and the risk of resistance to mupirocin in staphylococci. High-level mupirocin resistance in S. aureus can emerge through horizontal gene transfer originating from coagulase-negative staphylococci (CoNS) and through clonal transmission. The current evidence on the occurrence of high-level mupirocin resistance in S. aureus and CoNS, in combination with the results of mathematical modeling, strongly suggests that the increased selection of high-level mupirocin resistance in CoNS does not constitute an important risk for high-level mupirocin resistance in S. aureus. Compared with a targeted strategy, universal decolonization seems associated with an equally low risk of mupirocin resistance in S. aureus." @default.
- W2207128690 created "2016-06-24" @default.
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- W2207128690 date "2015-12-09" @default.
- W2207128690 modified "2023-10-15" @default.
- W2207128690 title "Prevention of Surgical Site Infections: Decontamination With Mupirocin Based on Preoperative Screening for<i>Staphylococcus aureus</i>Carriers or Universal Decontamination?" @default.
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- W2207128690 doi "https://doi.org/10.1093/cid/civ990" @default.
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