FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2207138264> ?p ?o ?g. }

• W2207138264 endingPage "272" @default.
• W2207138264 startingPage "266" @default.
• W2207138264 abstract "Background & Aims Spontaneous clearance of chronic hepatitis C virus (HCV) infection (CHC) is rare. We conducted a retrospective case-control study to identify rates and factors associated with spontaneous clearance of CHC. Methods We defined cases as individuals who spontaneously resolved CHC, and controls as individuals who remained chronically infected. We used data obtained on HCV testing between 1994 and 2013 in the West of Scotland to infer case/control status. Specifically, untreated patients with ⩾2 sequential samples positive for HCV RNA ⩾6 months apart followed by ⩾1 negative test, and those with ⩾2 positive samples ⩾6 months apart with no subsequent negative samples were identified. Control patients were randomly selected from the second group (4/patient of interest). Case notes were reviewed and patient characteristics obtained. Results 25,113 samples were positive for HCV RNA, relating to 10,318 patients. 50 cases of late spontaneous clearance were identified, contributing 241 person-years follow-up. 2,518 untreated, chronically infected controls were identified, contributing 13,766 person-years follow-up, from whom 200 controls were randomly selected. The incidence rate of spontaneous clearance was 0.36/100 person-years follow-up, occurring after a median 50 months’ infection. Spontaneous clearance was positively associated with female gender, younger age at infection, lower HCV RNA load and co-infection with hepatitis B virus. It was negatively associated with current intravenous drug use. Conclusions Spontaneous clearance of CHC occurs infrequently but is associated with identifiable host and viral factors. More frequent HCV RNA monitoring may be appropriate in selected patient groups. Lay summary Clearance of hepatitis C virus infection without treatment occurs rarely once chronic infection has been established. We interrogated a large Scottish patient cohort and found that it was more common in females, patients infected at a younger age or with lower levels of HCV in the blood, and patients co-infected with hepatitis B virus. Patients who injected drugs were less likely to spontaneously clear chronic infection. Spontaneous clearance of chronic hepatitis C virus (HCV) infection (CHC) is rare. We conducted a retrospective case-control study to identify rates and factors associated with spontaneous clearance of CHC. We defined cases as individuals who spontaneously resolved CHC, and controls as individuals who remained chronically infected. We used data obtained on HCV testing between 1994 and 2013 in the West of Scotland to infer case/control status. Specifically, untreated patients with ⩾2 sequential samples positive for HCV RNA ⩾6 months apart followed by ⩾1 negative test, and those with ⩾2 positive samples ⩾6 months apart with no subsequent negative samples were identified. Control patients were randomly selected from the second group (4/patient of interest). Case notes were reviewed and patient characteristics obtained. 25,113 samples were positive for HCV RNA, relating to 10,318 patients. 50 cases of late spontaneous clearance were identified, contributing 241 person-years follow-up. 2,518 untreated, chronically infected controls were identified, contributing 13,766 person-years follow-up, from whom 200 controls were randomly selected. The incidence rate of spontaneous clearance was 0.36/100 person-years follow-up, occurring after a median 50 months’ infection. Spontaneous clearance was positively associated with female gender, younger age at infection, lower HCV RNA load and co-infection with hepatitis B virus. It was negatively associated with current intravenous drug use. Spontaneous clearance of CHC occurs infrequently but is associated with identifiable host and viral factors. More frequent HCV RNA monitoring may be appropriate in selected patient groups." @default.
• W2207138264 created "2016-06-24" @default.
• W2207138264 creator A5007804720 @default.
• W2207138264 creator A5014084596 @default.
• W2207138264 creator A5014497784 @default.
• W2207138264 creator A5014587516 @default.
• W2207138264 creator A5021752244 @default.
• W2207138264 creator A5032253384 @default.
• W2207138264 creator A5032526180 @default.
• W2207138264 creator A5041959522 @default.
• W2207138264 creator A5051926617 @default.
• W2207138264 creator A5062766650 @default.
• W2207138264 creator A5081388535 @default.
• W2207138264 creator A5089502911 @default.
• W2207138264 date "2016-08-01" @default.
• W2207138264 modified "2023-10-06" @default.
• W2207138264 title "Factors associated with spontaneous clearance of chronic hepatitis C virus infection" @default.
• W2207138264 cites W1535288983 @default.
• W2207138264 cites W1964091672 @default.
• W2207138264 cites W1968935658 @default.
• W2207138264 cites W1985982900 @default.
• W2207138264 cites W1995876098 @default.
• W2207138264 cites W2004372194 @default.
• W2207138264 cites W2018167033 @default.
• W2207138264 cites W2022104878 @default.
• W2207138264 cites W2024122432 @default.
• W2207138264 cites W2025378444 @default.
• W2207138264 cites W2025581036 @default.
• W2207138264 cites W2050610759 @default.
• W2207138264 cites W2058538904 @default.
• W2207138264 cites W2064200008 @default.
• W2207138264 cites W2064738379 @default.
• W2207138264 cites W2064842824 @default.
• W2207138264 cites W2068185377 @default.
• W2207138264 cites W2072271760 @default.
• W2207138264 cites W2083138089 @default.
• W2207138264 cites W2094856729 @default.
• W2207138264 cites W2095706605 @default.
• W2207138264 cites W2098497882 @default.
• W2207138264 cites W2103489598 @default.
• W2207138264 cites W2106110144 @default.
• W2207138264 cites W2122900973 @default.
• W2207138264 cites W2123008311 @default.
• W2207138264 cites W2129955057 @default.
• W2207138264 cites W2132290252 @default.
• W2207138264 cites W2134194140 @default.
• W2207138264 cites W2137417346 @default.
• W2207138264 cites W2140174034 @default.
• W2207138264 cites W2142801043 @default.
• W2207138264 cites W2143454433 @default.
• W2207138264 cites W2144468748 @default.
• W2207138264 cites W2182249017 @default.
• W2207138264 cites W2312482815 @default.
• W2207138264 cites W2322277386 @default.
• W2207138264 cites W4211051574 @default.
• W2207138264 cites W4211077792 @default.
• W2207138264 cites W4244087112 @default.
• W2207138264 cites W4252324731 @default.
• W2207138264 doi "https://doi.org/10.1016/j.jhep.2016.04.030" @default.
• W2207138264 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27155531" @default.
• W2207138264 hasPublicationYear "2016" @default.
• W2207138264 type Work @default.
• W2207138264 sameAs 2207138264 @default.
• W2207138264 citedByCount "48" @default.
• W2207138264 countsByYear W22071382642017 @default.
• W2207138264 countsByYear W22071382642018 @default.
• W2207138264 countsByYear W22071382642019 @default.
• W2207138264 countsByYear W22071382642020 @default.
• W2207138264 countsByYear W22071382642021 @default.
• W2207138264 countsByYear W22071382642022 @default.
• W2207138264 countsByYear W22071382642023 @default.
• W2207138264 crossrefType "journal-article" @default.
• W2207138264 hasAuthorship W2207138264A5007804720 @default.
• W2207138264 hasAuthorship W2207138264A5014084596 @default.
• W2207138264 hasAuthorship W2207138264A5014497784 @default.
• W2207138264 hasAuthorship W2207138264A5014587516 @default.
• W2207138264 hasAuthorship W2207138264A5021752244 @default.
• W2207138264 hasAuthorship W2207138264A5032253384 @default.
• W2207138264 hasAuthorship W2207138264A5032526180 @default.
• W2207138264 hasAuthorship W2207138264A5041959522 @default.
• W2207138264 hasAuthorship W2207138264A5051926617 @default.
• W2207138264 hasAuthorship W2207138264A5062766650 @default.
• W2207138264 hasAuthorship W2207138264A5081388535 @default.
• W2207138264 hasAuthorship W2207138264A5089502911 @default.
• W2207138264 hasBestOaLocation W22071382642 @default.
• W2207138264 hasConcept C120665830 @default.
• W2207138264 hasConcept C121332964 @default.
• W2207138264 hasConcept C126322002 @default.
• W2207138264 hasConcept C142462285 @default.
• W2207138264 hasConcept C203014093 @default.
• W2207138264 hasConcept C2522874641 @default.
• W2207138264 hasConcept C2776408679 @default.
• W2207138264 hasConcept C2776455275 @default.
• W2207138264 hasConcept C61511704 @default.
• W2207138264 hasConcept C71924100 @default.
• W2207138264 hasConcept C90924648 @default.
• W2207138264 hasConceptScore W2207138264C120665830 @default.
• W2207138264 hasConceptScore W2207138264C121332964 @default.

• next