Matches in SemOpenAlex for { <https://semopenalex.org/work/W220717814> ?p ?o ?g. }
- W220717814 endingPage "1336" @default.
- W220717814 startingPage "1329" @default.
- W220717814 abstract "In this report, we extend our previous findings that IgG or F(ab′)2 fragments of HD37 anti-CD19 antibody (Ab) in combination with the immunotoxin (IT), RFB4-anti-CD22-deglycosylated ricin A chain (dgA) (but neither reagent alone), prolonged the survival of SCID mice with disseminated human Daudi lymphoma (SCID/Daudi mice) to 1 year at which time they still remained tumor-free. We explored the mechanisms by which the HD37 Ab exerts antitumor activity in vivo by studying its activity in vitro. We found that it has antiproliferative activity (IC50 = 5.2 - 9.8 x 10(-7) mol/L) on three CD19+ Burkitt's lymphoma cell lines (Daudi, Raji, and Namalwa) but not on a weakly CD19-positive (CD19lo) pre-B cell tumor (Nalm-6). The inhibitory effect was manifested by cell cycle arrest, but not apoptosis. Results using three additional anti-CD19 Abs, suggest that the affinity of the antibody and possibly the epitope which it recognizes may effect its capacity to transmit a signal that induces cell cycle arrest. Hence, therapeutically useful Abs may exert anti-tumor activity by a variety of mechanisms, each of which should be evaluated before undertaking clinical trials in humans." @default.
- W220717814 created "2016-06-24" @default.
- W220717814 creator A5003694937 @default.
- W220717814 creator A5064429049 @default.
- W220717814 creator A5068049564 @default.
- W220717814 creator A5080482273 @default.
- W220717814 creator A5084475433 @default.
- W220717814 creator A5088595140 @default.
- W220717814 date "1994-03-01" @default.
- W220717814 modified "2023-10-16" @default.
- W220717814 title "Anti-CD19 inhibits the growth of human B-cell tumor lines in vitro and of Daudi cells in SCID mice by inducing cell cycle arrest" @default.
- W220717814 cites W111063158 @default.
- W220717814 cites W1491206165 @default.
- W220717814 cites W1517196940 @default.
- W220717814 cites W1539984014 @default.
- W220717814 cites W1597399860 @default.
- W220717814 cites W1598727887 @default.
- W220717814 cites W1632189125 @default.
- W220717814 cites W1797510401 @default.
- W220717814 cites W1827669382 @default.
- W220717814 cites W1884715737 @default.
- W220717814 cites W1965047674 @default.
- W220717814 cites W1968273438 @default.
- W220717814 cites W1969450071 @default.
- W220717814 cites W1970579198 @default.
- W220717814 cites W1974568564 @default.
- W220717814 cites W1976692354 @default.
- W220717814 cites W2001593231 @default.
- W220717814 cites W2002126985 @default.
- W220717814 cites W2003285575 @default.
- W220717814 cites W2036751783 @default.
- W220717814 cites W2043761376 @default.
- W220717814 cites W2049463886 @default.
- W220717814 cites W2049775946 @default.
- W220717814 cites W2056151491 @default.
- W220717814 cites W2063756403 @default.
- W220717814 cites W2080058454 @default.
- W220717814 cites W2085977533 @default.
- W220717814 cites W2091673136 @default.
- W220717814 cites W2095614489 @default.
- W220717814 cites W2100624465 @default.
- W220717814 cites W2100837269 @default.
- W220717814 cites W2104639026 @default.
- W220717814 cites W2105053762 @default.
- W220717814 cites W2126949185 @default.
- W220717814 cites W2169441459 @default.
- W220717814 cites W2243999061 @default.
- W220717814 cites W2288396132 @default.
- W220717814 cites W2351157948 @default.
- W220717814 cites W2417849265 @default.
- W220717814 cites W2481718172 @default.
- W220717814 cites W33007984 @default.
- W220717814 cites W74992319 @default.
- W220717814 cites W78060682 @default.
- W220717814 doi "https://doi.org/10.1182/blood.v83.5.1329.bloodjournal8351329" @default.
- W220717814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7509655" @default.
- W220717814 hasPublicationYear "1994" @default.
- W220717814 type Work @default.
- W220717814 sameAs 220717814 @default.
- W220717814 citedByCount "39" @default.
- W220717814 countsByYear W2207178142013 @default.
- W220717814 countsByYear W2207178142015 @default.
- W220717814 countsByYear W2207178142017 @default.
- W220717814 countsByYear W2207178142019 @default.
- W220717814 countsByYear W2207178142021 @default.
- W220717814 crossrefType "journal-article" @default.
- W220717814 hasAuthorship W220717814A5003694937 @default.
- W220717814 hasAuthorship W220717814A5064429049 @default.
- W220717814 hasAuthorship W220717814A5068049564 @default.
- W220717814 hasAuthorship W220717814A5080482273 @default.
- W220717814 hasAuthorship W220717814A5084475433 @default.
- W220717814 hasAuthorship W220717814A5088595140 @default.
- W220717814 hasBestOaLocation W2207178141 @default.
- W220717814 hasConcept C105696609 @default.
- W220717814 hasConcept C115085202 @default.
- W220717814 hasConcept C150903083 @default.
- W220717814 hasConcept C153911025 @default.
- W220717814 hasConcept C159654299 @default.
- W220717814 hasConcept C16232356 @default.
- W220717814 hasConcept C185592680 @default.
- W220717814 hasConcept C190283241 @default.
- W220717814 hasConcept C202751555 @default.
- W220717814 hasConcept C203014093 @default.
- W220717814 hasConcept C207001950 @default.
- W220717814 hasConcept C2778453870 @default.
- W220717814 hasConcept C2778913318 @default.
- W220717814 hasConcept C2778957590 @default.
- W220717814 hasConcept C2779338263 @default.
- W220717814 hasConcept C29537977 @default.
- W220717814 hasConcept C502942594 @default.
- W220717814 hasConcept C542903549 @default.
- W220717814 hasConcept C54355233 @default.
- W220717814 hasConcept C55493867 @default.
- W220717814 hasConcept C81885089 @default.
- W220717814 hasConcept C86803240 @default.
- W220717814 hasConceptScore W220717814C105696609 @default.
- W220717814 hasConceptScore W220717814C115085202 @default.
- W220717814 hasConceptScore W220717814C150903083 @default.