Matches in SemOpenAlex for { <https://semopenalex.org/work/W2207263914> ?p ?o ?g. }
- W2207263914 endingPage "1789" @default.
- W2207263914 startingPage "1775" @default.
- W2207263914 abstract "The autophagy receptor CALCOCO2/NDP52 functions as a bridging adaptor and plays an essential role in the selective autophagic degradation of invading pathogens by specifically recognizing ubiquitin-coated intracellular pathogens and subsequently targeting them to the autophagic machinery; thereby it is required for innate immune defense against a range of infectious pathogens in mammals. However, the mechanistic basis underlying CALCOCO2-mediated specific recognition of ubiqutinated pathogens is still unknown. Here, using biochemical and structural analyses, we demonstrated that the cargo-binding region of CALCOCO2 contains a dynamic unconventional zinc finger as well as a C2H2-type zinc-finger, and only the C2H2-type zinc finger specifically recognizes mono-ubiquitin or poly-ubiquitin chains. In addition to elucidating the specific ubiquitin recognition mechanism of CALCOCO2, the structure of the CALCOCO2 C2H2-type zinc finger in complex with mono-ubiquitin also uncovers a unique zinc finger-binding mode for ubiquitin. Our findings provide mechanistic insight into how CALCOCO2 targets ubiquitin-decorated pathogens for autophagic degradations." @default.
- W2207263914 created "2016-06-24" @default.
- W2207263914 creator A5000238995 @default.
- W2207263914 creator A5003395715 @default.
- W2207263914 creator A5008696453 @default.
- W2207263914 creator A5012302243 @default.
- W2207263914 creator A5034699855 @default.
- W2207263914 creator A5036088068 @default.
- W2207263914 creator A5047497897 @default.
- W2207263914 creator A5059039565 @default.
- W2207263914 creator A5065418938 @default.
- W2207263914 date "2015-10-03" @default.
- W2207263914 modified "2023-10-16" @default.
- W2207263914 title "Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2" @default.
- W2207263914 cites W1501204944 @default.
- W2207263914 cites W1523693806 @default.
- W2207263914 cites W1555054913 @default.
- W2207263914 cites W1968351780 @default.
- W2207263914 cites W1968444524 @default.
- W2207263914 cites W1985469011 @default.
- W2207263914 cites W1986000139 @default.
- W2207263914 cites W1990619980 @default.
- W2207263914 cites W1992532731 @default.
- W2207263914 cites W1995017064 @default.
- W2207263914 cites W1995700909 @default.
- W2207263914 cites W1996152690 @default.
- W2207263914 cites W1996581963 @default.
- W2207263914 cites W1998019811 @default.
- W2207263914 cites W1999477136 @default.
- W2207263914 cites W2001045944 @default.
- W2207263914 cites W2002195659 @default.
- W2207263914 cites W2006114349 @default.
- W2207263914 cites W2009225398 @default.
- W2207263914 cites W2012167979 @default.
- W2207263914 cites W2012625663 @default.
- W2207263914 cites W2016765195 @default.
- W2207263914 cites W2016962320 @default.
- W2207263914 cites W2018636808 @default.
- W2207263914 cites W2021351468 @default.
- W2207263914 cites W2028536701 @default.
- W2207263914 cites W2030755802 @default.
- W2207263914 cites W2031544072 @default.
- W2207263914 cites W2034087770 @default.
- W2207263914 cites W2034167623 @default.
- W2207263914 cites W2035391125 @default.
- W2207263914 cites W2036468298 @default.
- W2207263914 cites W2038840577 @default.
- W2207263914 cites W2039454492 @default.
- W2207263914 cites W2040328910 @default.
- W2207263914 cites W2044621729 @default.
- W2207263914 cites W2048494900 @default.
- W2207263914 cites W2050043175 @default.
- W2207263914 cites W2051022720 @default.
- W2207263914 cites W2052247259 @default.
- W2207263914 cites W2052729357 @default.
- W2207263914 cites W2055390996 @default.
- W2207263914 cites W2056238689 @default.
- W2207263914 cites W2065031087 @default.
- W2207263914 cites W2067458397 @default.
- W2207263914 cites W2067958753 @default.
- W2207263914 cites W2076544864 @default.
- W2207263914 cites W2076769172 @default.
- W2207263914 cites W2077743844 @default.
- W2207263914 cites W2077757969 @default.
- W2207263914 cites W2078709018 @default.
- W2207263914 cites W2085470568 @default.
- W2207263914 cites W2086020129 @default.
- W2207263914 cites W2087250844 @default.
- W2207263914 cites W2088967049 @default.
- W2207263914 cites W2097481253 @default.
- W2207263914 cites W2101090646 @default.
- W2207263914 cites W2102420546 @default.
- W2207263914 cites W2106195012 @default.
- W2207263914 cites W2108086395 @default.
- W2207263914 cites W2113174533 @default.
- W2207263914 cites W2115888489 @default.
- W2207263914 cites W2122339645 @default.
- W2207263914 cites W2124753099 @default.
- W2207263914 cites W2130381855 @default.
- W2207263914 cites W2140915719 @default.
- W2207263914 cites W2144081223 @default.
- W2207263914 cites W2156171182 @default.
- W2207263914 cites W2157096314 @default.
- W2207263914 cites W2164945122 @default.
- W2207263914 cites W2949250147 @default.
- W2207263914 cites W4236258478 @default.
- W2207263914 doi "https://doi.org/10.1080/15548627.2015.1082025" @default.
- W2207263914 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4824588" @default.
- W2207263914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26506893" @default.
- W2207263914 hasPublicationYear "2015" @default.
- W2207263914 type Work @default.
- W2207263914 sameAs 2207263914 @default.
- W2207263914 citedByCount "58" @default.
- W2207263914 countsByYear W22072639142016 @default.
- W2207263914 countsByYear W22072639142017 @default.
- W2207263914 countsByYear W22072639142018 @default.
- W2207263914 countsByYear W22072639142019 @default.
- W2207263914 countsByYear W22072639142020 @default.