FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2207368474> ?p ?o ?g. }

• W2207368474 endingPage "783" @default.
• W2207368474 startingPage "778" @default.
• W2207368474 abstract "Little progress has been made over the past several years in the treatment of gram-negative bacteremia and septic shock. Advances in biotechnology have led to the development of human monoclonal antibody against endotoxin (HA-1A), a toxic mediator of the septic response. HA-1A is an immunoglobulin M antibody to the lipid A component of the endotoxin molecule. It distributes into an apparent volume of distribution 10–20 percent larger than plasma volume and has a circulating half-life of 16.0 hours. In a major, multicenter, double-blind trial of HA-1A 100 mg administered intravenously versus placebo, mortality was greatly reduced in HA-1A recipients with gram-negative bacteremia. Increased survival was noted early and was sustained throughout the 28-day study period in patients with and without shock at the time of enrollment. HA-1A has an excellent safety profile; thus far only two minor hypersensitivity reactions and no drug interactions have been reported. Based on currently available information, the release of HA-1A as adjunct therapy for patients with gram-negative bacteremia with or without shock represents a significant therapeutic advance. Investigations are underway to define the optimal dose of HA-1A and its duration of action. Comparative trials between HA-1A and competitive products are necessary." @default.
• W2207368474 created "2016-06-24" @default.
• W2207368474 creator A5024748503 @default.
• W2207368474 date "1991-07-01" @default.
• W2207368474 modified "2023-10-04" @default.
• W2207368474 title "Human Monoclonal Antibody against Endotoxin" @default.
• W2207368474 cites W1480366980 @default.
• W2207368474 cites W1965323794 @default.
• W2207368474 cites W1992644897 @default.
• W2207368474 cites W2000421482 @default.
• W2207368474 cites W2006887827 @default.
• W2207368474 cites W2012328356 @default.
• W2207368474 cites W2014781329 @default.
• W2207368474 cites W2028184568 @default.
• W2207368474 cites W2038434279 @default.
• W2207368474 cites W2039602526 @default.
• W2207368474 cites W2045010042 @default.
• W2207368474 cites W2055656655 @default.
• W2207368474 cites W2064107559 @default.
• W2207368474 cites W2070540495 @default.
• W2207368474 cites W2072117769 @default.
• W2207368474 cites W2072486140 @default.
• W2207368474 cites W2083895304 @default.
• W2207368474 cites W2089179708 @default.
• W2207368474 cites W2132100196 @default.
• W2207368474 cites W2146732421 @default.
• W2207368474 cites W2150538311 @default.
• W2207368474 cites W2319070317 @default.
• W2207368474 cites W2328804315 @default.
• W2207368474 cites W2396863730 @default.
• W2207368474 cites W2403377899 @default.
• W2207368474 cites W4233474789 @default.
• W2207368474 cites W4234776673 @default.
• W2207368474 cites W4300562921 @default.
• W2207368474 doi "https://doi.org/10.1177/106002809102500714" @default.
• W2207368474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1949939" @default.
• W2207368474 hasPublicationYear "1991" @default.
• W2207368474 type Work @default.
• W2207368474 sameAs 2207368474 @default.
• W2207368474 citedByCount "3" @default.
• W2207368474 crossrefType "journal-article" @default.
• W2207368474 hasAuthorship W2207368474A5024748503 @default.
• W2207368474 hasConcept C126322002 @default.
• W2207368474 hasConcept C142724271 @default.
• W2207368474 hasConcept C144464004 @default.
• W2207368474 hasConcept C159654299 @default.
• W2207368474 hasConcept C203014093 @default.
• W2207368474 hasConcept C204787440 @default.
• W2207368474 hasConcept C27081682 @default.
• W2207368474 hasConcept C2777628635 @default.
• W2207368474 hasConcept C2778384902 @default.
• W2207368474 hasConcept C2778754761 @default.
• W2207368474 hasConcept C2779443120 @default.
• W2207368474 hasConcept C2781300812 @default.
• W2207368474 hasConcept C501593827 @default.
• W2207368474 hasConcept C535046627 @default.
• W2207368474 hasConcept C542903549 @default.
• W2207368474 hasConcept C71924100 @default.
• W2207368474 hasConcept C86803240 @default.
• W2207368474 hasConcept C89423630 @default.
• W2207368474 hasConcept C98274493 @default.
• W2207368474 hasConceptScore W2207368474C126322002 @default.
• W2207368474 hasConceptScore W2207368474C142724271 @default.
• W2207368474 hasConceptScore W2207368474C144464004 @default.
• W2207368474 hasConceptScore W2207368474C159654299 @default.
• W2207368474 hasConceptScore W2207368474C203014093 @default.
• W2207368474 hasConceptScore W2207368474C204787440 @default.
• W2207368474 hasConceptScore W2207368474C27081682 @default.
• W2207368474 hasConceptScore W2207368474C2777628635 @default.
• W2207368474 hasConceptScore W2207368474C2778384902 @default.
• W2207368474 hasConceptScore W2207368474C2778754761 @default.
• W2207368474 hasConceptScore W2207368474C2779443120 @default.
• W2207368474 hasConceptScore W2207368474C2781300812 @default.
• W2207368474 hasConceptScore W2207368474C501593827 @default.
• W2207368474 hasConceptScore W2207368474C535046627 @default.
• W2207368474 hasConceptScore W2207368474C542903549 @default.
• W2207368474 hasConceptScore W2207368474C71924100 @default.
• W2207368474 hasConceptScore W2207368474C86803240 @default.
• W2207368474 hasConceptScore W2207368474C89423630 @default.
• W2207368474 hasConceptScore W2207368474C98274493 @default.
• W2207368474 hasIssue "7-8" @default.
• W2207368474 hasLocation W22073684741 @default.
• W2207368474 hasLocation W22073684742 @default.
• W2207368474 hasOpenAccess W2207368474 @default.
• W2207368474 hasPrimaryLocation W22073684741 @default.
• W2207368474 hasRelatedWork W2055180099 @default.
• W2207368474 hasRelatedWork W2065030849 @default.
• W2207368474 hasRelatedWork W2065102252 @default.
• W2207368474 hasRelatedWork W2230543585 @default.
• W2207368474 hasRelatedWork W2234542263 @default.
• W2207368474 hasRelatedWork W2443906695 @default.
• W2207368474 hasRelatedWork W2742862736 @default.
• W2207368474 hasRelatedWork W2912853550 @default.
• W2207368474 hasRelatedWork W2980471702 @default.
• W2207368474 hasRelatedWork W4387035054 @default.
• W2207368474 hasVolume "25" @default.
• W2207368474 isParatext "false" @default.
• W2207368474 isRetracted "false" @default.

• next