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• W2207663673 abstract "LG72 can increase mitochondrial ROSs and oxidative stress has been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS). The serum level of LG72 or LG72-related molecules might therefore be associated with ALS. Here, we aim to determine the serum autoantibody against LG72 has potential as a biomarker for the diagnosis of ALS.Seventy-eighty patients with ALS, 45 patients with AD, 43 patients with PD and 88 healthy adults were enrolled.The concentration of serum autoantibody against LG72 was more than fourfold lower in ALS than other control groups (p < 0.001). The AUC was 0.9627 when the cut-off value for autoantibody concentration was 0.167 μg/ml.This finding suggests that the autoantibody against LG72 might serve as a surrogate biomarker for ALS." @default.
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• W2207663673 date "2016-01-01" @default.
• W2207663673 modified "2023-10-13" @default.
• W2207663673 title "Decreased level of serum autoantibody against LG72 is a biosignature of amyotrophic lateral sclerosis" @default.
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• W2207663673 doi "https://doi.org/10.2217/bmm.15.80" @default.
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