FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2207685258> ?p ?o ?g. }

• W2207685258 endingPage "1096" @default.
• W2207685258 startingPage "1090" @default.
• W2207685258 abstract "An increasing body of evidence is pointing towards mitochondrial regulation of the cell cycle. In a previous study of HER2-positive tumours we could demonstrate a common loss in the gene encoding for the mitochondrial transporter SLC25A43 and also a significant relation between SLC25A43 protein expression and S-phase fraction. Here, we investigated the consequence of suppressed SLC25A43 expression on cell cycle progression and proliferation in breast epithelial cells. In the present study, we suppressed SLC25A43 using siRNA in immortalised non-cancerous breast epithelial MCF10A cells and HER2-positive breast cancer cells BT-474. Viability, apoptosis, cell proliferation rate, cell cycle phase distribution, and nuclear Ki-67 and p21, were assessed by flow cytometry. Cell cycle related gene expressions were analysed using real-time PCR. We found that SLC25A43 knockdown in MCF10A cells significantly inhibited cell cycle progression during G1-to-S transition, thus significantly reducing the proliferation rate and fraction of Ki-67 positive MCF10A cells. In contrast, suppressed SLC25A43 expression in BT-474 cells resulted in a significantly increased proliferation rate together with an enhanced G1-to-S transition. This was reflected by an increased fraction of Ki-67 positive cells and reduced level of nuclear p21. In line with our previous results, we show a role for SLC25A43 as a regulator of cell cycle progression and proliferation through a putative mitochondrial checkpoint. These novel data further strengthen the connection between mitochondrial function and the cell cycle, both in non-malignant and in cancer cells." @default.
• W2207685258 created "2016-06-24" @default.
• W2207685258 creator A5015828385 @default.
• W2207685258 creator A5036297155 @default.
• W2207685258 creator A5044198521 @default.
• W2207685258 creator A5047591350 @default.
• W2207685258 date "2016-01-01" @default.
• W2207685258 modified "2023-10-03" @default.
• W2207685258 title "Mitochondrial regulation of cell cycle progression through SLC25A43" @default.
• W2207685258 cites W1509669696 @default.
• W2207685258 cites W1605269201 @default.
• W2207685258 cites W1974188155 @default.
• W2207685258 cites W1979389283 @default.
• W2207685258 cites W1980116041 @default.
• W2207685258 cites W1986599999 @default.
• W2207685258 cites W1989041007 @default.
• W2207685258 cites W1993626201 @default.
• W2207685258 cites W1994857926 @default.
• W2207685258 cites W2010112859 @default.
• W2207685258 cites W2011912935 @default.
• W2207685258 cites W2014758663 @default.
• W2207685258 cites W2016620855 @default.
• W2207685258 cites W2022837882 @default.
• W2207685258 cites W2026285983 @default.
• W2207685258 cites W2031897237 @default.
• W2207685258 cites W2041787200 @default.
• W2207685258 cites W2045881846 @default.
• W2207685258 cites W2068351003 @default.
• W2207685258 cites W2081920342 @default.
• W2207685258 cites W2089218510 @default.
• W2207685258 cites W2095960563 @default.
• W2207685258 cites W2100659636 @default.
• W2207685258 cites W2111420633 @default.
• W2207685258 cites W2117692326 @default.
• W2207685258 cites W2138205640 @default.
• W2207685258 cites W2139860222 @default.
• W2207685258 cites W2159023635 @default.
• W2207685258 cites W2161791301 @default.
• W2207685258 cites W2167805612 @default.
• W2207685258 doi "https://doi.org/10.1016/j.bbrc.2015.12.088" @default.
• W2207685258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26721434" @default.
• W2207685258 hasPublicationYear "2016" @default.
• W2207685258 type Work @default.
• W2207685258 sameAs 2207685258 @default.
• W2207685258 citedByCount "7" @default.
• W2207685258 countsByYear W22076852582017 @default.
• W2207685258 countsByYear W22076852582019 @default.
• W2207685258 countsByYear W22076852582020 @default.
• W2207685258 countsByYear W22076852582022 @default.
• W2207685258 countsByYear W22076852582023 @default.
• W2207685258 crossrefType "journal-article" @default.
• W2207685258 hasAuthorship W2207685258A5015828385 @default.
• W2207685258 hasAuthorship W2207685258A5036297155 @default.
• W2207685258 hasAuthorship W2207685258A5044198521 @default.
• W2207685258 hasAuthorship W2207685258A5047591350 @default.
• W2207685258 hasConcept C105696609 @default.
• W2207685258 hasConcept C1491633281 @default.
• W2207685258 hasConcept C153911025 @default.
• W2207685258 hasConcept C190283241 @default.
• W2207685258 hasConcept C25311885 @default.
• W2207685258 hasConcept C29537977 @default.
• W2207685258 hasConcept C502942594 @default.
• W2207685258 hasConcept C54355233 @default.
• W2207685258 hasConcept C553184892 @default.
• W2207685258 hasConcept C62112901 @default.
• W2207685258 hasConcept C86803240 @default.
• W2207685258 hasConcept C95444343 @default.
• W2207685258 hasConceptScore W2207685258C105696609 @default.
• W2207685258 hasConceptScore W2207685258C1491633281 @default.
• W2207685258 hasConceptScore W2207685258C153911025 @default.
• W2207685258 hasConceptScore W2207685258C190283241 @default.
• W2207685258 hasConceptScore W2207685258C25311885 @default.
• W2207685258 hasConceptScore W2207685258C29537977 @default.
• W2207685258 hasConceptScore W2207685258C502942594 @default.
• W2207685258 hasConceptScore W2207685258C54355233 @default.
• W2207685258 hasConceptScore W2207685258C553184892 @default.
• W2207685258 hasConceptScore W2207685258C62112901 @default.
• W2207685258 hasConceptScore W2207685258C86803240 @default.
• W2207685258 hasConceptScore W2207685258C95444343 @default.
• W2207685258 hasFunder F4320322581 @default.
• W2207685258 hasIssue "4" @default.
• W2207685258 hasLocation W22076852581 @default.
• W2207685258 hasLocation W22076852582 @default.
• W2207685258 hasOpenAccess W2207685258 @default.
• W2207685258 hasPrimaryLocation W22076852581 @default.
• W2207685258 hasRelatedWork W2350169822 @default.
• W2207685258 hasRelatedWork W2350294409 @default.
• W2207685258 hasRelatedWork W2354128257 @default.
• W2207685258 hasRelatedWork W2354735832 @default.
• W2207685258 hasRelatedWork W2374592133 @default.
• W2207685258 hasRelatedWork W2379033026 @default.
• W2207685258 hasRelatedWork W2382230817 @default.
• W2207685258 hasRelatedWork W2388602301 @default.
• W2207685258 hasRelatedWork W2389851268 @default.
• W2207685258 hasRelatedWork W3032847486 @default.
• W2207685258 hasVolume "469" @default.
• W2207685258 isParatext "false" @default.
• W2207685258 isRetracted "false" @default.

• next