FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2207694898> ?p ?o ?g. }

• W2207694898 endingPage "e0144275" @default.
• W2207694898 startingPage "e0144275" @default.
• W2207694898 abstract "In prokaryotes simple sequence repeats (SSRs) with unit sizes of 1-5 nucleotides (nt) are causative for phase and antigenic variation. Although an increased abundance of heptameric repeats was noticed in bacteria, reports about SSRs of 6-9 nt are rare. In particular G-rich repeat sequences with the propensity to fold into G-quadruplex (G4) structures have received little attention. In silico analysis of prokaryotic genomes show putative G4 forming sequences to be abundant. This report focuses on a surprisingly enriched G-rich repeat of the type GGGNATC in Xanthomonas and cyanobacteria such as Nostoc. We studied in detail the genomes of Xanthomonas campestris pv. campestris ATCC 33913 (Xcc), Xanthomonas axonopodis pv. citri str. 306 (Xac), and Nostoc sp. strain PCC7120 (Ana). In all three organisms repeats are spread all over the genome with an over-representation in non-coding regions. Extensive variation of the number of repetitive units was observed with repeat numbers ranging from two up to 26 units. However a clear preference for four units was detected. The strong bias for four units coincides with the requirement of four consecutive G-tracts for G4 formation. Evidence for G4 formation of the consensus repeat sequences was found in biophysical studies utilizing CD spectroscopy. The G-rich repeats are preferably located between aligned open reading frames (ORFs) and are under-represented in coding regions or between divergent ORFs. The G-rich repeats are preferentially located within a distance of 50 bp upstream of an ORF on the anti-sense strand or within 50 bp from the stop codon on the sense strand. Analysis of whole transcriptome sequence data showed that the majority of repeat sequences are transcribed. The genetic loci in the vicinity of repeat regions show increased genomic stability. In conclusion, we introduce and characterize a special class of highly abundant and wide-spread quadruplex-forming repeat sequences in bacteria." @default.
• W2207694898 created "2016-06-24" @default.
• W2207694898 creator A5009251667 @default.
• W2207694898 creator A5015808361 @default.
• W2207694898 creator A5016867920 @default.
• W2207694898 creator A5024631305 @default.
• W2207694898 creator A5077253315 @default.
• W2207694898 date "2015-12-22" @default.
• W2207694898 modified "2023-10-06" @default.
• W2207694898 title "Investigation of a Quadruplex-Forming Repeat Sequence Highly Enriched in Xanthomonas and Nostoc sp." @default.
• W2207694898 cites W1043439854 @default.
• W2207694898 cites W1568027445 @default.
• W2207694898 cites W1902452511 @default.
• W2207694898 cites W1935193003 @default.
• W2207694898 cites W1968330084 @default.
• W2207694898 cites W1970383168 @default.
• W2207694898 cites W1977413761 @default.
• W2207694898 cites W1978317672 @default.
• W2207694898 cites W1984388559 @default.
• W2207694898 cites W1990635146 @default.
• W2207694898 cites W1990802269 @default.
• W2207694898 cites W1997352668 @default.
• W2207694898 cites W2001418158 @default.
• W2207694898 cites W2004432131 @default.
• W2207694898 cites W2006025260 @default.
• W2207694898 cites W2010999047 @default.
• W2207694898 cites W2011657487 @default.
• W2207694898 cites W2012932968 @default.
• W2207694898 cites W2013356258 @default.
• W2207694898 cites W2016491299 @default.
• W2207694898 cites W2020652742 @default.
• W2207694898 cites W2021191052 @default.
• W2207694898 cites W2021385406 @default.
• W2207694898 cites W2024283144 @default.
• W2207694898 cites W2034048377 @default.
• W2207694898 cites W2039272200 @default.
• W2207694898 cites W2040976733 @default.
• W2207694898 cites W2048063734 @default.
• W2207694898 cites W2049415064 @default.
• W2207694898 cites W2062169797 @default.
• W2207694898 cites W2062677544 @default.
• W2207694898 cites W2064100312 @default.
• W2207694898 cites W2067220993 @default.
• W2207694898 cites W2068447445 @default.
• W2207694898 cites W2070883648 @default.
• W2207694898 cites W2071918742 @default.
• W2207694898 cites W2076843089 @default.
• W2207694898 cites W2077507837 @default.
• W2207694898 cites W2081175059 @default.
• W2207694898 cites W2083390725 @default.
• W2207694898 cites W2092006462 @default.
• W2207694898 cites W2092424765 @default.
• W2207694898 cites W2099553504 @default.
• W2207694898 cites W2100658004 @default.
• W2207694898 cites W2108528950 @default.
• W2207694898 cites W2109892747 @default.
• W2207694898 cites W2113333419 @default.
• W2207694898 cites W2114499303 @default.
• W2207694898 cites W2116609429 @default.
• W2207694898 cites W2118208047 @default.
• W2207694898 cites W2119360625 @default.
• W2207694898 cites W2121642311 @default.
• W2207694898 cites W2121672428 @default.
• W2207694898 cites W2124582915 @default.
• W2207694898 cites W2126419817 @default.
• W2207694898 cites W2128345861 @default.
• W2207694898 cites W2129028297 @default.
• W2207694898 cites W2131271579 @default.
• W2207694898 cites W2133305872 @default.
• W2207694898 cites W2136145671 @default.
• W2207694898 cites W2139295688 @default.
• W2207694898 cites W2142528785 @default.
• W2207694898 cites W2143587090 @default.
• W2207694898 cites W2148660588 @default.
• W2207694898 cites W2149459456 @default.
• W2207694898 cites W2149919973 @default.
• W2207694898 cites W2154050062 @default.
• W2207694898 cites W2155590708 @default.
• W2207694898 cites W2158266834 @default.
• W2207694898 cites W2158714788 @default.
• W2207694898 cites W2159482845 @default.
• W2207694898 cites W2159577277 @default.
• W2207694898 cites W2160679365 @default.
• W2207694898 cites W2162205254 @default.
• W2207694898 cites W2163255170 @default.
• W2207694898 cites W2166160777 @default.
• W2207694898 cites W2170551349 @default.
• W2207694898 cites W2170754011 @default.
• W2207694898 cites W2171039375 @default.
• W2207694898 cites W2171787842 @default.
• W2207694898 cites W2171830519 @default.
• W2207694898 cites W2173267258 @default.
• W2207694898 cites W2332158618 @default.
• W2207694898 cites W4294216483 @default.
• W2207694898 cites W2437362552 @default.
• W2207694898 doi "https://doi.org/10.1371/journal.pone.0144275" @default.
• W2207694898 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4692102" @default.
• W2207694898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26695179" @default.

• next