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• W2207738462 abstract "C ANCER CHEMOTHERAPY is ideally directed to the selective destruction of neoplastic cells. Unfortunately, the selectivity factor is imperfect and with currently available drugs, damage to normal tissues does occur. All chemotherapeutic agents cause significant toxicity whether or not they have any concurrent benefit, and medical oncologists and their patients recognize this unfortunate fact. An evaluation of the worth of any chemotherapeutic regimen must be analyzed as cost versus benefit, in which the benefit is tumor regression and the cost is host toxicity. Currently, more than thirty drugs that are effective in treating at least one kind of human malignancy are available to the clinical oncologist. All of these drugs have some degree of toxic potential for normal cells; just as there is a unique spectrum of tumors responsive to each drug, so each drug has its unique range of toxic potential. Since cancer chemotherapy is predicated on the cell-kill hypothesis and the concept of the first order kinetics of tumor cell kill, these drugs are usually given at the highest dosages patients can possibly tolerate. It is assumed that the higher the dose, the higher the fraction of tumor cells that will be destroyed and the closer the patient will be to having the tumor completely eradicated. Even when properly administered, all cancer drugs must by definition cause some degree of toxicity. The experienced oncologist learns to titrate his drug doses to achieve both maximal tumor cell kill and tolerable toxicity. Because of the increase in both the number of chemotherapeutic drugs and of patients being treated, the literature dealing with clinical drug toxicity has grown. Many possible ways of classifying and describing the panoply of toxicities have emerged. We have found it convenient and useful to classify these toxicities by two criteria: (1) predictability, and (2) frequency of occurrence. Some toxicities occur commonly and frequently and will consistently increase in specific situations; e.g., in combination with certain drugs or in patients having determinate preexisting conditions. Other toxicities occur uncommonly and unexpect-" @default.
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• W2207738462 date "1978-06-01" @default.
• W2207738462 modified "2023-09-23" @default.
• W2207738462 title "Serious toxicities associated with chemotherapy." @default.
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