Matches in SemOpenAlex for { <https://semopenalex.org/work/W2207788762> ?p ?o ?g. }
- W2207788762 endingPage "2019" @default.
- W2207788762 startingPage "2007" @default.
- W2207788762 abstract "Retention of lipoproteins within the vasculature is a central event in the pathogenesis of atherosclerosis. However, the signals that mediate this process are only partially understood. Prompted by putative links between inflammation and atherosclerosis, we previously reported that alpha-defensins released by neutrophils are present in human atherosclerotic lesions and promote the binding of lipoprotein(a) [Lp(a)] to vascular cells without a concomitant increase in degradation. We have now tested the hypothesis that this accumulation results from the propensity of defensin to form stable complexes with Lp(a) that divert the lipoprotein from its normal cellular degradative pathways to the extracellular matrix (ECM). In accord with this hypothesis, defensin stimulated the binding of Lp(a) to vascular matrices approximately 40-fold and binding of the reactants to the matrix was essentially irreversible. Defensin formed stable, multivalent complexes with Lp(a) and with its components, apoprotein (a) and low-density lipoprotein (LDL), as assessed by optical biosensor analysis, gel filtration, and immunoelectron microscopy. Binding of defensin/Lp(a) complexes to matrix was inhibited (>90%) by heparin and by antibodies to fibronectin (>70%), but not by antibodies to vitronectin or thrombospondin. Defensin increased the binding of Lp(a) (10 nmol/L) to purified fibronectin more than 30-fold. Whereas defensin and Lp(a) readily traversed the endothelial cell membranes individually, defensin/Lp(a) complexes lodged on the cell surface. These studies demonstrate that alpha-defensins released from activated or senescent neutrophils stimulate the binding of an atherogenic lipoprotein to the ECM of endothelial cells, a process that may contribute to lipoprotein accumulation in atherosclerotic lesions." @default.
- W2207788762 created "2016-06-24" @default.
- W2207788762 creator A5007250467 @default.
- W2207788762 creator A5013936515 @default.
- W2207788762 creator A5018821561 @default.
- W2207788762 creator A5035815172 @default.
- W2207788762 creator A5039803568 @default.
- W2207788762 creator A5041880715 @default.
- W2207788762 creator A5046162064 @default.
- W2207788762 creator A5051123834 @default.
- W2207788762 creator A5060354594 @default.
- W2207788762 creator A5068247678 @default.
- W2207788762 creator A5071375483 @default.
- W2207788762 creator A5074858430 @default.
- W2207788762 creator A5077478635 @default.
- W2207788762 creator A5087092637 @default.
- W2207788762 creator A5089793470 @default.
- W2207788762 creator A5089911552 @default.
- W2207788762 date "1999-09-15" @default.
- W2207788762 modified "2023-09-28" @default.
- W2207788762 title "Defensin Promotes the Binding of Lipoprotein(a) to Vascular Matrix" @default.
- W2207788762 cites W1485802716 @default.
- W2207788762 cites W1510767762 @default.
- W2207788762 cites W1534966313 @default.
- W2207788762 cites W1535386959 @default.
- W2207788762 cites W1564262981 @default.
- W2207788762 cites W182155550 @default.
- W2207788762 cites W1907444416 @default.
- W2207788762 cites W1927237973 @default.
- W2207788762 cites W1931276869 @default.
- W2207788762 cites W1966508061 @default.
- W2207788762 cites W1968171440 @default.
- W2207788762 cites W1970910357 @default.
- W2207788762 cites W1974216938 @default.
- W2207788762 cites W1975168532 @default.
- W2207788762 cites W1975420360 @default.
- W2207788762 cites W1978174334 @default.
- W2207788762 cites W1991998151 @default.
- W2207788762 cites W1994360551 @default.
- W2207788762 cites W1995859867 @default.
- W2207788762 cites W2001691760 @default.
- W2207788762 cites W2002114986 @default.
- W2207788762 cites W2004391976 @default.
- W2207788762 cites W2004893917 @default.
- W2207788762 cites W2005087516 @default.
- W2207788762 cites W2005760069 @default.
- W2207788762 cites W2007178040 @default.
- W2207788762 cites W2009100337 @default.
- W2207788762 cites W2010933740 @default.
- W2207788762 cites W2017809305 @default.
- W2207788762 cites W2022577580 @default.
- W2207788762 cites W2022853507 @default.
- W2207788762 cites W2023525921 @default.
- W2207788762 cites W2023814923 @default.
- W2207788762 cites W2024884860 @default.
- W2207788762 cites W2026236910 @default.
- W2207788762 cites W2031510621 @default.
- W2207788762 cites W2032242304 @default.
- W2207788762 cites W2032524811 @default.
- W2207788762 cites W2032731208 @default.
- W2207788762 cites W2034457606 @default.
- W2207788762 cites W2036170644 @default.
- W2207788762 cites W2045868118 @default.
- W2207788762 cites W2050385895 @default.
- W2207788762 cites W2052303496 @default.
- W2207788762 cites W2052911190 @default.
- W2207788762 cites W2053607106 @default.
- W2207788762 cites W2057726272 @default.
- W2207788762 cites W2058342634 @default.
- W2207788762 cites W2061797776 @default.
- W2207788762 cites W2063502677 @default.
- W2207788762 cites W2067098330 @default.
- W2207788762 cites W2071382325 @default.
- W2207788762 cites W2078571162 @default.
- W2207788762 cites W2078877062 @default.
- W2207788762 cites W2080815938 @default.
- W2207788762 cites W2083845392 @default.
- W2207788762 cites W2093535758 @default.
- W2207788762 cites W2094522465 @default.
- W2207788762 cites W2097580954 @default.
- W2207788762 cites W2104630130 @default.
- W2207788762 cites W2108451194 @default.
- W2207788762 cites W2123035356 @default.
- W2207788762 cites W2123631149 @default.
- W2207788762 cites W2125546202 @default.
- W2207788762 cites W2125727048 @default.
- W2207788762 cites W2125905957 @default.
- W2207788762 cites W2133772687 @default.
- W2207788762 cites W2134138509 @default.
- W2207788762 cites W2136145860 @default.
- W2207788762 cites W2137570167 @default.
- W2207788762 cites W2139983966 @default.
- W2207788762 cites W2140337240 @default.
- W2207788762 cites W2140385393 @default.
- W2207788762 cites W2165773709 @default.
- W2207788762 cites W2167591919 @default.
- W2207788762 cites W2200241148 @default.
- W2207788762 cites W2207166403 @default.