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- W2207989660 abstract "Impaired glucose tolerance (IGT) is a strong risk factor for Type 2 diabetes and cardiovascular disease. The aim of this study was to validate and implement a previously published fasting predictive tool for IGT in obese children: TG > 1.17 mmol /L, which showed a 71.4[57.8–85.1]% sensitivity and a 64.1[57.7–70.4]% specificity in 259 obese Canadian children. The possible contribution of other metabolic variables was evaluated by assessing the net reclassification improvement (NRI). 817 Italian obese children (8–18.4 years) were recruited and underwent fasting blood analysis and oral glucose tolerance test (OGTT). Thirty-nine children (4.7%) had IGT. The 1.17 mmol/L TG threshold showed 66.6 [51.8–81.4]% sensitivity and 68.2 [64.9–71.5]% specificity, thus successfully validated. Fasting plasma glucose (FPG) was independently associated with IGT (OR = 3.86 [2.09–7.14], P 1.13 mmol/L plus FPG > 4.44 mmol/L had a 69.2[54.7–83.7]% sensitivity and a 78.2[76.8–79.6]% specificity, thus displaying a 12.6% NRI ( P 1.17 mmol/L. TG > 1.17 mmol/L is a useful criterion to detect roughly 66% of obese children with IGT through OGTT performed in about 33% of all obese children. However, the ‘TG > 1.13 mmol/L plus FPG > 4.44 mmol/L’ criterion allows for detecting even more than 66% of obese children with IGT, though limiting OGTT to just 25% of all obese children." @default.
- W2207989660 created "2016-06-24" @default.
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- W2207989660 date "2014-05-01" @default.
- W2207989660 modified "2023-09-23" @default.
- W2207989660 title "Screening for impaired glucose tolerance in obese children and adolescents. A validation and implementation study." @default.
- W2207989660 doi "https://doi.org/10.1016/j.appet.2014.01.024" @default.
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