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• W2208122053 abstract "Early life stress can disrupt development and negatively impact long-term health trajectories. Reconstructing histories of early life exposure to external stressors is hampered by the absence of retrospective time-specific biomarkers. Defects in tooth enamel have been used to reconstruct stress but the methods used are subjective and do not identify the specific biological systems impacted by external stressors. Here we show that external physical and social stressors impart biochemical signatures in primate teeth that can be retrieved to objectively reconstruct the timing of early life developmental disruptions. Using teeth from captive macaques, we uncovered elemental imprints specific to disruptions of skeletal growth, including major disruptions in body weight trajectory and moderate to severe illnesses. Discrete increases in heat shock protein-70 expression in dentine coincided with elemental signatures, confirming that elemental signals were associated with activation of stress-related pathways. To overcome limitations of conventional light-microscopic analysis, we used high resolution Raman microspectral imaging to identify structural and compositional alterations in enamel and dentine that coincided with elemental signatures and with detailed medical and behavioural data. Integrating these objective biochemical markers with temporal mapping of teeth enables the retrospective study of early life developmental disruptions and their ensuing health sequelae." @default.
• W2208122053 created "2016-06-24" @default.
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• W2208122053 date "2016-01-04" @default.
• W2208122053 modified "2023-10-01" @default.
• W2208122053 title "Uncovering system-specific stress signatures in primate teeth with multimodal imaging" @default.
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• W2208122053 doi "https://doi.org/10.1038/srep18802" @default.
• W2208122053 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4698674" @default.
• W2208122053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26727334" @default.
• W2208122053 hasPublicationYear "2016" @default.
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