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- W2208181 abstract "Publisher Summary This chapter discusses fluctuation experiments on the sodium channels of nerve. Rapid gating currents of nerve membranes, which are thought to be associated with the activation of Na channels, are reversibly blocked by depolarization. The block resembles the inactivation process of Na channels by its voltage and time dependence. This observation, and the absence of gating current attributable to the inactivation process, has led to propose a reaction scheme where inactivation requires partial or complete activation and where, in turn, inactivation prevents a complete reversal of activation. Two kinds of fluctuation experiments have been devised for testing this hypothesis in an independent way. The open probability of Na channels at the peak of the Na current is determined. Channels that inactivate only after they have become activated have by this time a larger chance to be open than channels that can inactivate at any time after a depolarizing step." @default.
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- W2208181 date "1981-01-01" @default.
- W2208181 modified "2023-09-25" @default.
- W2208181 title "FLUCTUATION EXPERIMENTS ON SODIUM CHANNELS OF NERVE" @default.
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- W2208181 doi "https://doi.org/10.1016/b978-0-08-026816-3.50012-2" @default.
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