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- W2208341544 abstract "Diclofenac is the most widely-used non-steroidal anti-inflammatory drug (NSAID) in Europe. Almost twenty years of use in humans have shown that this drug is effective, useful and well tolerated in general [1] despite a few drawbacks concerning (a) the variable and incomplete oral bioavailability [2], and (b) the intensive and immediate oxidative metabolization in the liver [2] which is possibly associated with a measurable and clinical relevant hepatotoxicity [5,6,10]. Recent findings revealed that the well-known hepatotoxicity of paracetamol is related to the production of an unstable reactive electrophilic metabolite [8]. We suppose that similar metabolic processes may occur with diclofenac resulting in comparable reactive metabolites. Moreover, recent observations by Sato and his co-workers have indicated that the co-administration of other drugs may enhance the production of hepatotoxic metabolites of paracetamol [9,10] and, thus, enhance this clinically relevant phenomenon. Similar effects appear possible with diclofenac. They may contribute to the putative toxicity of this drug." @default.
- W2208341544 created "2016-06-24" @default.
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- W2208341544 date "1992-01-01" @default.
- W2208341544 modified "2023-09-26" @default.
- W2208341544 title "Increased liver toxicity of diclofenac by paracetamol: results and possible mechanisms" @default.
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- W2208341544 doi "https://doi.org/10.1007/978-94-011-2982-4_24" @default.
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