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- W2208519199 endingPage "e0141462" @default.
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- W2208519199 abstract "Pancreatic fibrosis, a prominent feature of chronic pancreatitis (CP), induces persistent and permanent damage in the pancreas. Pancreatic stellate cells (PSCs) provide a major source of extracellular matrix (ECM) deposition during pancreatic injury, and persistent activation of PSCs plays a vital role in the progression of pancreatic fibrosis. Retinoic acid (RA), a retinoid, has a broad range of biological functions, including regulation of cell differentiation and proliferation, attenuating progressive fibrosis of multiple organs. In the present study, we investigated the effects of RA on fibrosis in experimental CP and cultured PSCs. CP was induced in mice by repetitive cerulein injection in vivo, and mouse PSCs were isolated and activated in vitro. Suppression of pancreatic fibrosis upon administration of RA was confirmed based on reduction of histological damage, α-smooth muscle actin (α-SMA) expression and mRNA levels of β-catenin, platelet-derived growth factor (PDGF)-Rβ transforming growth factor (TGF)-βRII and collagen 1α1 in vivo. Wnt 2 and β-catenin protein levels were markedly down-regulated, while Axin 2 expression level was up-regulated in the presence of RA, both in vivo and in vitro. Nuclear translation of β-catenin was significantly decreased following RA treatment, compared with cerulein-induced CP in mice and activated PSCs. Furthermore, RA induced significant PSC apoptosis, inhibited proliferation, suppressed TCF/LEF-dependent transcriptional activity and ECM production of PSC via down-regulation of TGFβRII, PDGFRβ and collagen 1α1 in vitro. These results indicate a critical role of the Wnt/β-catenin signaling pathway in RA-induced effects on CP and PSC regulation and support the potential of RA as a suppressor of pancreatic fibrosis in mice." @default.
- W2208519199 created "2016-06-24" @default.
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- W2208519199 date "2015-11-10" @default.
- W2208519199 modified "2023-10-02" @default.
- W2208519199 title "Retinoic Acid Ameliorates Pancreatic Fibrosis and Inhibits the Activation of Pancreatic Stellate Cells in Mice with Experimental Chronic Pancreatitis via Suppressing the Wnt/β-Catenin Signaling Pathway" @default.
- W2208519199 cites W1482687321 @default.
- W2208519199 cites W1566119898 @default.
- W2208519199 cites W1585930836 @default.
- W2208519199 cites W1967483023 @default.
- W2208519199 cites W1971085650 @default.
- W2208519199 cites W1973147485 @default.
- W2208519199 cites W1974847328 @default.
- W2208519199 cites W1978148663 @default.
- W2208519199 cites W1983712244 @default.
- W2208519199 cites W1984067840 @default.
- W2208519199 cites W198765271 @default.
- W2208519199 cites W1989657088 @default.
- W2208519199 cites W1989732890 @default.
- W2208519199 cites W1990448161 @default.
- W2208519199 cites W1992995822 @default.
- W2208519199 cites W1993600822 @default.
- W2208519199 cites W1996558263 @default.
- W2208519199 cites W2004362570 @default.
- W2208519199 cites W2005492562 @default.
- W2208519199 cites W2008720321 @default.
- W2208519199 cites W2011091185 @default.
- W2208519199 cites W2011556781 @default.
- W2208519199 cites W2011877672 @default.
- W2208519199 cites W2013891209 @default.
- W2208519199 cites W2014235909 @default.
- W2208519199 cites W2014738732 @default.
- W2208519199 cites W2016871060 @default.
- W2208519199 cites W2018650295 @default.
- W2208519199 cites W2026429762 @default.
- W2208519199 cites W2027140244 @default.
- W2208519199 cites W2027176350 @default.
- W2208519199 cites W2027550738 @default.
- W2208519199 cites W2044433805 @default.
- W2208519199 cites W2046402557 @default.
- W2208519199 cites W2052605153 @default.
- W2208519199 cites W2060081030 @default.
- W2208519199 cites W2060286302 @default.
- W2208519199 cites W2068075681 @default.
- W2208519199 cites W2069065842 @default.
- W2208519199 cites W2078822299 @default.
- W2208519199 cites W2087951894 @default.
- W2208519199 cites W2089117732 @default.
- W2208519199 cites W2090709209 @default.
- W2208519199 cites W2095090793 @default.
- W2208519199 cites W2100584502 @default.
- W2208519199 cites W2102164563 @default.
- W2208519199 cites W2102512718 @default.
- W2208519199 cites W2107648723 @default.
- W2208519199 cites W2111888125 @default.
- W2208519199 cites W2115481097 @default.
- W2208519199 cites W2120395649 @default.
- W2208519199 cites W2121652346 @default.
- W2208519199 cites W2141520345 @default.
- W2208519199 cites W2148294117 @default.
- W2208519199 cites W2149637294 @default.
- W2208519199 cites W2155507705 @default.
- W2208519199 cites W2155510164 @default.
- W2208519199 cites W2160152459 @default.
- W2208519199 cites W2162431704 @default.
- W2208519199 cites W2168521667 @default.
- W2208519199 cites W2169560003 @default.
- W2208519199 cites W2191331809 @default.
- W2208519199 cites W2327153377 @default.
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- W2208519199 doi "https://doi.org/10.1371/journal.pone.0141462" @default.
- W2208519199 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4640570" @default.
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- W2208519199 hasPublicationYear "2015" @default.
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