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- W2208588003 abstract "Cytochrome P450 (CYP450) inhibition by the bioactive molecules of herbs leading to greater potential for toxicity of co-administered drugs. Diosgenin is an important bioactive steroidal sapogenin from Dioscorea bulbifera belonging to the triterpene group and is of great interest to the pharmaceutical industry. The purpose of this study was, to find whether D. bulbifera and Diosgenin influences the effect on rat CYP450 enzymes and its important isoforms (CYP3A4, CYP2D6) by using high through put screening. CYP450-CO Complex assay was performed in rat pooled liver microsomes to calculate percentage inhibition of test samples on CYP450. IC values were determined by fluorometric assays of CYP3A4 and CYP2D6. Mode of inhibition of Diosgenin on these CYPs were further assessed by molecular docking studies with the Glide (Schrodinger Inc. U.S.A.). In CYP450 inhibition assay, the inhibitory potential of herb extract (40.44±1.28 %) was found to be less than positive control (72.08±1.96 %). In fluorometric assay, he..." @default.
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- W2208588003 date "2015-09-03" @default.
- W2208588003 modified "2023-09-26" @default.
- W2208588003 title "Effect ofDioscorea bulbiferaand its Major Bioactive Compound, Diosgenin on CYP450 Mediated Drug Metabolism" @default.
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- W2208588003 doi "https://doi.org/10.1080/22311866.2015.1108229" @default.
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