FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2208651278> ?p ?o ?g. }

• W2208651278 abstract "Acute appendicitis (AA) (OMIM: 107700) is an inflammatory disease which is characterized by appendiceal inflammation. Genetic and environmental factors contribute to the development of AA. Especially, multiple genetic factors appear to be promising in the explanation of etiopathogenesis of AA. IL-6 (Interleukin-6) is an inflammatory cytokine and IL-6 receptor (IL-6R) plays an important role in the immune response. IL-6 (-572G/C rs1800796) and IL-6R (1:G.154448302 T > C rs7529229) gene polymorphisms may have an impact on cytokine production, immune response and these gene polymorphisms may be used as inflammatory markers in the diagnosis of appendicitis. A total of 75 children with appendicitis, and 75 healthy children were included in the study. DNA extracts were obtained from peripheral lymphocytes. Single-nucleotide polymorphisms (SNPs) were analysed using an automated SYBR® Green RT-PCR system in pediatric patients with appendicitis (n = 75) and healthy controls (n = 75). The allele and genotype frequencies for IL-6 rs1800796 and IL-6R rs7529229 polymorphisms were not different between the study groups (p > 0.05). Any statistically significant differences as for age, sex and other laboratory factors were not detected between the patients with appendicitis for genotype-allele frequencies (p > 0.05). Still in analyses performed to determine correlations among age, and gender of the patients, routine laboratory parameters and allele-genotype frequencies, a statistically significant intergroup difference was not detected. Genotype and allele frequencies were consistent with Hardy-Weinberg equilibrium (HWE) in all groups. This is the first study to investigate the effects of functional two polymorphisms on IL-6 and IL-6R genes in a pediatric patient group with AA risk. With this study we investigated the contribution of IL-6 (-572G/C rs1800796) and IL-6R (1:G.154448302 T > C rs7529229) polymorphisms on pathogenesis, and severity of AA in pediatric patients with AA: These results will guide further genetic researches to be performed on the role of IL-6 and IL-6R in AA. Given the putative biological importance of this SNPs, these emerging data can provide a new foundation to stimulate future debate and genetic investigations of AA, focusing on new molecular mechanisms such as other IL gene polymorphisms, particularly in accessible peripheral tissues for novel molecular diagnostics for appendicitis." @default.
• W2208651278 created "2016-06-24" @default.
• W2208651278 creator A5000327812 @default.
• W2208651278 creator A5029035264 @default.
• W2208651278 creator A5074520805 @default.
• W2208651278 creator A5078961292 @default.
• W2208651278 creator A5082383696 @default.
• W2208651278 creator A5090663386 @default.
• W2208651278 date "2015-12-01" @default.
• W2208651278 modified "2023-09-27" @default.
• W2208651278 title "Polymorphisms in the IL-6 and IL-6R receptor genes as new diagnostic biomarkers of acute appendicitis: a study on two candidate genes in pediatric patients with acute appendicitis" @default.
• W2208651278 cites W1840567140 @default.
• W2208651278 cites W1964156915 @default.
• W2208651278 cites W1965830523 @default.
• W2208651278 cites W1979649586 @default.
• W2208651278 cites W1980373323 @default.
• W2208651278 cites W1984763799 @default.
• W2208651278 cites W1990420040 @default.
• W2208651278 cites W1995279474 @default.
• W2208651278 cites W1999040820 @default.
• W2208651278 cites W2007066741 @default.
• W2208651278 cites W2019802104 @default.
• W2208651278 cites W2024460772 @default.
• W2208651278 cites W2028990156 @default.
• W2208651278 cites W2029062869 @default.
• W2208651278 cites W2038321220 @default.
• W2208651278 cites W2055342544 @default.
• W2208651278 cites W2064012533 @default.
• W2208651278 cites W2065479473 @default.
• W2208651278 cites W2085866528 @default.
• W2208651278 cites W2094523576 @default.
• W2208651278 cites W2100478793 @default.
• W2208651278 cites W2109009575 @default.
• W2208651278 cites W2138963221 @default.
• W2208651278 cites W2139502021 @default.
• W2208651278 cites W2146666438 @default.
• W2208651278 cites W2167031236 @default.
• W2208651278 cites W2182371873 @default.
• W2208651278 cites W2394972085 @default.
• W2208651278 cites W2758054396 @default.
• W2208651278 cites W4231356340 @default.
• W2208651278 doi "https://doi.org/10.1186/s13052-015-0206-7" @default.
• W2208651278 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4696224" @default.
• W2208651278 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26714766" @default.
• W2208651278 hasPublicationYear "2015" @default.
• W2208651278 type Work @default.
• W2208651278 sameAs 2208651278 @default.
• W2208651278 citedByCount "6" @default.
• W2208651278 countsByYear W22086512782018 @default.
• W2208651278 countsByYear W22086512782019 @default.
• W2208651278 countsByYear W22086512782020 @default.
• W2208651278 countsByYear W22086512782021 @default.
• W2208651278 countsByYear W22086512782022 @default.
• W2208651278 crossrefType "journal-article" @default.
• W2208651278 hasAuthorship W2208651278A5000327812 @default.
• W2208651278 hasAuthorship W2208651278A5029035264 @default.
• W2208651278 hasAuthorship W2208651278A5074520805 @default.
• W2208651278 hasAuthorship W2208651278A5078961292 @default.
• W2208651278 hasAuthorship W2208651278A5082383696 @default.
• W2208651278 hasAuthorship W2208651278A5090663386 @default.
• W2208651278 hasBestOaLocation W22086512781 @default.
• W2208651278 hasConcept C104317684 @default.
• W2208651278 hasConcept C126322002 @default.
• W2208651278 hasConcept C135763542 @default.
• W2208651278 hasConcept C141071460 @default.
• W2208651278 hasConcept C153209595 @default.
• W2208651278 hasConcept C175239580 @default.
• W2208651278 hasConcept C180754005 @default.
• W2208651278 hasConcept C203014093 @default.
• W2208651278 hasConcept C2780016130 @default.
• W2208651278 hasConcept C37463918 @default.
• W2208651278 hasConcept C54355233 @default.
• W2208651278 hasConcept C71924100 @default.
• W2208651278 hasConcept C86803240 @default.
• W2208651278 hasConcept C8891405 @default.
• W2208651278 hasConcept C90924648 @default.
• W2208651278 hasConceptScore W2208651278C104317684 @default.
• W2208651278 hasConceptScore W2208651278C126322002 @default.
• W2208651278 hasConceptScore W2208651278C135763542 @default.
• W2208651278 hasConceptScore W2208651278C141071460 @default.
• W2208651278 hasConceptScore W2208651278C153209595 @default.
• W2208651278 hasConceptScore W2208651278C175239580 @default.
• W2208651278 hasConceptScore W2208651278C180754005 @default.
• W2208651278 hasConceptScore W2208651278C203014093 @default.
• W2208651278 hasConceptScore W2208651278C2780016130 @default.
• W2208651278 hasConceptScore W2208651278C37463918 @default.
• W2208651278 hasConceptScore W2208651278C54355233 @default.
• W2208651278 hasConceptScore W2208651278C71924100 @default.
• W2208651278 hasConceptScore W2208651278C86803240 @default.
• W2208651278 hasConceptScore W2208651278C8891405 @default.
• W2208651278 hasConceptScore W2208651278C90924648 @default.
• W2208651278 hasIssue "1" @default.
• W2208651278 hasLocation W22086512781 @default.
• W2208651278 hasLocation W22086512782 @default.
• W2208651278 hasLocation W22086512783 @default.
• W2208651278 hasLocation W22086512784 @default.
• W2208651278 hasOpenAccess W2208651278 @default.
• W2208651278 hasPrimaryLocation W22086512781 @default.
• W2208651278 hasRelatedWork W170155097 @default.
• W2208651278 hasRelatedWork W1988408892 @default.

• next