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- W2208657728 abstract "Abstract Objective To analyze the relationship between the age-adjusted Charlson comorbidity index (aCCI) and pathological outcomes of transurethral resection of de novo bladder tumors (BT). Material and methods Data from 208 patients who underwent a transurethral resection (TUR) of a de novo BT between 2007 and 2008 were collected. We recorded the following variables: age, sex, tobacco consumption, comorbidities assessed according to the aCCI (score and mortality rate), disease stage, tumor grade and risk of recurrence and progression. The relationship between the preoperative variables and the final pathological characteristics was analyzed. The multivariate study was conducted with the significant variables ( p Results The mean age of the patients was 69.5 ± 12 years, and 77% were men. The mean aCCI was 6.4 ± 2.5. The final pathology results showed a Tx, T0, Ta, T1 and ≥T2 in 5.3, 6.7, 31.7, 26.9, and 28.8% of the cases, respectively. 33.3% of the tumors were low-grade and 66.7% were high-grade. 14.3% of the tumors were associated with carcinoma in situ. Among those non musculo-invasive bladder tumor (non-MIBT), 34.7% had a low risk of recurrence and progression, 18.1% had an intermediate risk and 47.2% had a high risk. The patients with a aCCI ≥5 had an increased number of MIBT (RR: 2.29; 1.1–4.8; p = .032), high-grade tumors (RR: 3.1; CI: 1.6–6; p = .001) and tumors with a high risk of recurrence and progression (RR: 2.9; CI: 1.4–5.9; p Conclusion The aCCI is related to the pathological characteristics of de novo BT. Patients with greater comorbidity can present more aggressive tumors. The aCCI could therefore be useful in clinical practice for identifying patients with worse prognosis." @default.
- W2208657728 created "2016-06-24" @default.
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- W2208657728 date "2016-01-01" @default.
- W2208657728 modified "2023-09-26" @default.
- W2208657728 title "A higher Charlson comorbidity index is related to more aggressive characteristics in de novo vesical tumors" @default.
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- W2208657728 doi "https://doi.org/10.1016/j.acuroe.2015.11.011" @default.
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