FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2208708143> ?p ?o ?g. }

• W2208708143 abstract "Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 antagonist represents the mainstay of therapy for prevention of ischemic events in high-risk patients after acute coronary syndrome (ACS) and in those undergoing percutaneous coronary intervention (PCI). Over the last 2 decades, the arsenal of antithrombotic agents available to clinicians has rapidly expanded, contributing to step-wise declines in cardiovascular mortality after ACS and PCI.1 In this setting, clinically significant bleeding complications, particularly gastrointestinal bleeding, remain a major barrier to intensifying antiplatelet inhibition.2 Strategies to attenuate this excess gastrointestinal risk are limited. Proton pump inhibitors (PPI) have been demonstrated to reduce gastrointestinal bleeding3 and patient-reported dyspepsia4 in patients receiving DAPT. As such, gastroprotection with PPIs in patients requiring DAPT at high risk for bleeding events is supported by consensus guidelines.5,6See Article by Weisz et al Clopidogrel remains the most widely prescribed P2Y12 inhibitor worldwide, largely related to clinician familiarity and affordability. Given frequent co-administration of clopidogrel and PPI therapy, their common hepatic metabolism, and the consequences of suboptimal therapeutic effects, clarifying a possible adverse pharmacological interaction between these agents has been an ongoing substantial research effort. Indeed, regulatory agencies have issued formal statements highlighting the potential safety hazards of concurrent use of clopidogrel and certain PPIs (namely, omeprazole and esomeprazole). Despite new data generated in this space and increased attention from regulatory and research fronts, it remains unclear whether the pharmacokinetic and pharmacodynamic interaction between clopidogrel and PPIs has any real-world clinical implications.PPIs may reduce the availability of the biologically active metabolite of clopidogrel by competitively inhibiting cytochrome P450 2C19 (CYP2C19), one of the isozymes responsible for the step-wise hepatic oxidation and subsequent hydroxylation of the thienopyridine prodrug.7 Heterogeneity exists in the inhibitory effects of specific PPIs on CYP2C19 isozymes. …" @default.
• W2208708143 created "2016-06-24" @default.
• W2208708143 creator A5026004870 @default.
• W2208708143 creator A5061881316 @default.
• W2208708143 date "2015-10-01" @default.
• W2208708143 modified "2023-09-23" @default.
• W2208708143 title "Revisiting the Clopidogrel–Proton Pump Inhibitor Interaction" @default.
• W2208708143 cites W1597382752 @default.
• W2208708143 cites W1815519940 @default.
• W2208708143 cites W1990333964 @default.
• W2208708143 cites W1995259829 @default.
• W2208708143 cites W2004868154 @default.
• W2208708143 cites W2017501956 @default.
• W2208708143 cites W2030887397 @default.
• W2208708143 cites W2071687773 @default.
• W2208708143 cites W2081030005 @default.
• W2208708143 cites W2082149672 @default.
• W2208708143 cites W2090210165 @default.
• W2208708143 cites W2099022345 @default.
• W2208708143 cites W2102393690 @default.
• W2208708143 cites W2112857503 @default.
• W2208708143 cites W2119951798 @default.
• W2208708143 cites W2121169735 @default.
• W2208708143 cites W2129147195 @default.
• W2208708143 cites W2145218953 @default.
• W2208708143 cites W2152376036 @default.
• W2208708143 cites W2157833432 @default.
• W2208708143 cites W2548564186 @default.
• W2208708143 cites W2883081813 @default.
• W2208708143 doi "https://doi.org/10.1161/circinterventions.115.003208" @default.
• W2208708143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26458412" @default.
• W2208708143 hasPublicationYear "2015" @default.
• W2208708143 type Work @default.
• W2208708143 sameAs 2208708143 @default.
• W2208708143 citedByCount "3" @default.
• W2208708143 countsByYear W22087081432016 @default.
• W2208708143 countsByYear W22087081432020 @default.
• W2208708143 crossrefType "journal-article" @default.
• W2208708143 hasAuthorship W2208708143A5026004870 @default.
• W2208708143 hasAuthorship W2208708143A5061881316 @default.
• W2208708143 hasBestOaLocation W22087081431 @default.
• W2208708143 hasConcept C121332964 @default.
• W2208708143 hasConcept C126322002 @default.
• W2208708143 hasConcept C2777628954 @default.
• W2208708143 hasConcept C2777849778 @default.
• W2208708143 hasConcept C2781025758 @default.
• W2208708143 hasConcept C54516573 @default.
• W2208708143 hasConcept C62520636 @default.
• W2208708143 hasConcept C71924100 @default.
• W2208708143 hasConcept C98274493 @default.
• W2208708143 hasConceptScore W2208708143C121332964 @default.
• W2208708143 hasConceptScore W2208708143C126322002 @default.
• W2208708143 hasConceptScore W2208708143C2777628954 @default.
• W2208708143 hasConceptScore W2208708143C2777849778 @default.
• W2208708143 hasConceptScore W2208708143C2781025758 @default.
• W2208708143 hasConceptScore W2208708143C54516573 @default.
• W2208708143 hasConceptScore W2208708143C62520636 @default.
• W2208708143 hasConceptScore W2208708143C71924100 @default.
• W2208708143 hasConceptScore W2208708143C98274493 @default.
• W2208708143 hasIssue "10" @default.
• W2208708143 hasLocation W22087081431 @default.
• W2208708143 hasLocation W22087081432 @default.
• W2208708143 hasOpenAccess W2208708143 @default.
• W2208708143 hasPrimaryLocation W22087081431 @default.
• W2208708143 hasRelatedWork W1859232251 @default.
• W2208708143 hasRelatedWork W1998449260 @default.
• W2208708143 hasRelatedWork W2011519534 @default.
• W2208708143 hasRelatedWork W2024206888 @default.
• W2208708143 hasRelatedWork W2046794402 @default.
• W2208708143 hasRelatedWork W2071687773 @default.
• W2208708143 hasRelatedWork W2076472818 @default.
• W2208708143 hasRelatedWork W2110602156 @default.
• W2208708143 hasRelatedWork W2117933369 @default.
• W2208708143 hasRelatedWork W2359827248 @default.
• W2208708143 hasVolume "8" @default.
• W2208708143 isParatext "false" @default.
• W2208708143 isRetracted "false" @default.
• W2208708143 magId "2208708143" @default.
• W2208708143 workType "article" @default.